Research in the Osman lab is both basic mechanistic and translational, focused on the mechanisms governing cell homeostasis and their dysfunction in human disease. Using well-established and new technology the Osman lab investigates signaling networks that underlie complex diseases, and aims at identifying biomarkers and drug targets.
Three main projects are being pursued to define how a newly identified pathway regulates the mTORC1-S6K negative feedback on insulin signaling and cell proliferation, links cancer and diabetes and how it mediates infection-generated cancers
Mahasin Osman received her Ph.D. from Cornell University in Biochemistry Cell and Molecular Biology. Her postdoctoral work also at Cornell focused on cell polarity and cytokinesis and was the first to define yeast IQGAP as the now widely used secretion marker in cytokinesis. As a Research Scientist with independent laboratory funded by the National Cancer Institute her laboratory identified a unique signaling pathway that couples cell growth and division and regulates the mTORC1/S6K-Akt axis, and which links cancer and metabolic disease
MAHASIN OSMAN, Ph.D
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