Prof. Knopf's career interest has been in protein biosynthesis, initially in general but primarily in immunoglobulins and their role as antibodies in humoral immune reponses. Since joining the Brown faculty, he has studied protective antibody responses to worm and protozoan parasitic infections (vaccine development against schistosomiasis and malaria), responses to antigens in the brain (autoimmunity), and most recently the role of complement C3d in the induction of the T-dependent antibody response.
As an immunologist, I am intrigued by how the immune system responds to challenges. I first took an interest in biology as an undergraduate majoring in physics at MIT. After going on to receive a doctorate in biophysics from MIT, I completed post-doctoral training at the Medical Research Council Laboratory for Molecular Biology in England, and the Salk Institute. I came to Brown in 1972.
PAUL M. KNOPF, PhD
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