Anne De Groot is a nationally recognized expert in epitope-driven vaccines and has been working on TB, HIV (AIDS), HPV (Cervical Cancer) and more recently, smallpox and tularemia vaccines. She has emphasized the development of vaccines that are globally relevant and affordable to the persons at greatest risk of disease. She devotes 80% of her effort to directing the scientific affairs of EpiVax, a biotech company located in Providence, where she is CEO and Chief Scientific Officer.

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Anne S. De Groot, M.D.

Associate Professor of Pediatrics (Adjunct), Brown University School of Medicine
Former Director, TB/HIV Research Lab (Brown University)
Director, Institute for Immunology and Informatics, University of Rhode Island (I'Cubed)
Founder, CEO & President, EpiVax, Inc.

Dr. De Groot earned degrees from Smith College (BA, 1978) and the Pritzker School of Medicine at the University of Chicago (MD, 1983). She was trained in internal medicine at New England Medical Center (1986), and then went on to complete additional training in immunoinformatics and vaccine research under Jay Berzofsky at the NIH (1989). Following her fellowship at the NIH, she returned to NEMC for clinical training in infectious disease (1991). She was board certified in Internal Medicine in 1986 and in Infectious Disease in 1992. In 1992, she joined the faculty of the Brown University Medical School, where she opened the TB/HIV Research Laboratory. She designed the EpiMatrix algorithm at Brown University with the assistance of Gabe Meister, Bill Jesdale and Bill Martin. With Bill, she founded EpiVax in 1998 and licensed the EpiMatrix technology. She has been the CEO/CSO and President of EpiVax since 1998.

At EpiVax, Dr. De Groot supervises the science and business strategies at EpiVax. She spends one per week on academic pursuits at Brown University, where she is Associate Professor of Medicine and Community Health and at University of Rhode Island where she teaches vaccinology to undergraduate students (Spring Semester) and provides clinical care to patients at the Rhode Island TB clinic one afternoon per week. She founded and edited IDCR (1998-2008) and is founder and Scientific Director of the GAIA Vaccine Foundation (501c3, 2002). In addition to her active research on vaccines, she is a pioneer in the field of deimmunisation (of protein therapeutics). She and Bill Martin developed the DeFT approach to reengineering protein pharmaceuticals in 2002 and discovered "Epi-13" also known as "Tregitope", new molecules with potential for the treatment of autoimmune diseases, in 2007.

De Groot has received more than $26M in uninterrupted federal funding for her research activities through multiple NIH (K08, R21, R01, SBIR) and foundation grants since 1989. She was the recipient of a National Foundation for Infectious Diseases-Eli Lilly Award, two Rhode Island Foundation awards and a Commercial Innovation Award (from the Rhode Island Center for Cellular Medicine). In 2003 she was recognized by Women and Infants Hospital as "Woman of the Year in Science". She was recognized as one of the "Best and the Brightest" in Science and Technology by Esquire Magazine (2003) for her work on the GAIA HIV vaccine. In 2006 she was named "Doctor of the Year" by the Rhode Island Medical Women's Association. In 2007 she received the Al Fisher "Red Ribbon Award" for her AIDS work in West Africa, from AIDS Project Rhode Island. She has published more than 100 articles and chapters describing the development of epitope-driven vaccines and the application of immunoinformatics tools.

She nourished a productive laboratory (the TB/HIV Research Laboratory) at Brown before shifting her primary effort from Brown to EpiVax in 2006. As CEO of EpiVax, she successfully established client relationships with Amgen, Eli Lilly, Wyeth, Pfizer, Roche, Abbott and a range of smaller biotech companies. In 2009 she was awarded a $13M grant from the NIH to set up a new institute at the University of Rhode Island, where she is now Professor (Research). As of May 2011 she resigned from Brown University Medical School and now runs an NIH-funded Institute for Immunology and Informatics at the University of Rhode Island. Information on the iCubed can be found at

Curricum Vitae

Download Anne De Groot's Curriculum Vitae in PDF Format

ANNE DE GROOT, MD, University of Chicago
Associate Professor (Research, Adjunct)
Pediatric (Infectious Disease)
Phone: +1 401 272 2123
Phone 2: +1 401 952 4227
E-mail: AnnieD@Brown.EDU

Anne De Groot's Brown Research URL:

On The Web:
Hunt for HIV/AIDS vaccine a community effort (GSJ of May 31, 2002)
De Groot's research places her at forefront of push for HIV vaccine (GSJ of May 28, 2004)
Infectious Diseases in Corrections Report
GAIA Vaccine Foundation
Information on "Epi-13" Tregitopes
"Medical Angel"
She Shines Award 2008
Publication on 'Tregitopes' in Blood Journal of October 2008
URI names EpiVax founder to head Institute for Immunology & Informatics 12 Feb 2009
Taking Action (Boston Herald October 2009)
Institute for Immunology and Informatics
Clinica Esperanza/Hope Clinic
Career Achievement Award (2010)
De Groot named "Top Doctor" in Knowledge District

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