RICHARD FREIMAN

Our laboratory is interested in deciphering mechanisms of gene expression patterns critical for proper organ development and function in mammals. We primarily use gene targeting in the mouse as a genetic tool to perturb the normal function of gene regulatory proteins in mammalian development. As an application of our research, we aim to understand how the disruption of normal gene expression networks may affect the etiology of disease states in humans, such as infertility and ovarian cancer.

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Biography

Richard Freiman is molecular geneticist studying fundamental mechanisms of transcriptional regulation in mammalian development and human disease. Before joining the Brown faculty in 2003, Dr. Freiman completed graduate training in mechanisms garnering eukaryotic transcriptional regulation. He received his Ph.D. in Genetics from SUNY Stony Brook in 1997. His thesis research, conducted at Cold Spring Harbor Laboratory, involved elucidation of critical host cell-viral interactions regulating viral and cellular gene expression programs. In 1998, he moved to UC Berkeley where he conducted postdoctoral studies on mechanisms of tissue-specific gene expression. This work led to the discovery that components of general transcription factor complexes play direct and selective roles in mammalian development. He continues this research at Brown, using gene targeting in the mouse as the primary tool to characterize transcriptional regulators in mammalian development and human disease. He teaches courses on developmental biology, chromatin and transcription and sex determination.

Curricum Vitae

Download Richard Freiman's Curriculum Vitae in PDF Format

RICHARD FREIMAN, B.S., Ph.D.
Associate Professor of Medical Science
Molecular Biology, Cell Biology, & Biochemistry
Phone: +1 401 863 9633
E-mail: Richard_Freiman@brown.edu

Richard Freiman's Brown Research URL:
http://research.brown.edu/myresearch/Richard_Freiman

On The Web:
New Life Sciences Faculty 2003
Surprising Pair of Proteins Help Make Healthy Eggs
New Scholar Award in Aging

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