Dr. Dubielecka is an Associate Professor of Medicine at the Alpert Medical School of Brown University and Director of Translational Hematology within the Division of Hematology/Oncology in the Department of Medicine at the Rhode Island Hospital. Dr. Dubielecka is a Co-Director of Pathobiology Graduate Program at Brown University and a Co-Leader of the Cancer Biology Program at the Legorreta Cancer Center at Brown University. Dr. Dubielecka received her undergraduate (summa cum laude) and PhD degrees (with honors) from the University of Wroclaw, Poland. She was a scholar of the Socrates/Erasmus Program established by the European Commission, and trained at the University of Helsinki, Finland and at Charles University in Hradec Kralove, Czech Republic. Dr. Dubielecka did her postdoctoral training at the Lindsley F. Kimball Research Institute in New York and was a visiting scientist in training at the University of Michigan, Ann Arbor and Helmholtz Centre for Infection Research in Braunschweig, Germany. Dr. Dubielecka established her independent scientific program in 2012. Her program is focused on the biology of blood cancer-initiating stem cells and their role in the development, progression and relapse of myeloproliferative neoplasms with the translational goal of therapeutically targeting neoplasm-initiating stem cells.
| Siamwala JH, Pagano FS, Dubielecka PM, Ivey MJ, Guirao-Abad JP, Zhao A, Chen S, Granston H, Jeong JY, Rounds S, Kanisicak O, Sadayappan S, Gilbert RJ. "IL-1β-mediated adaptive reprogramming of endogenous human cardiac fibroblasts to cells with immune features during fibrotic remodeling." Communications biology, vol. 6, no. 1, 2023, pp. 1200. |
| Wang L, Kulthinee S, Slate-Romano J, Zhao T, Shanmugam H, Dubielecka PM, Zhang LX, Qin G, Zhuang S, Chin YE, Zhao TC. "Inhibition of integrin alpha v/beta 5 mitigates the protective effect induced by irisin in hemorrhage." Experimental and molecular pathology, vol. 134, 2023, pp. 104869. |
| Wang J, Zhao YT, Zhang LX, Dubielecka PM, Qin G, Chin YE, Gower AC, Zhuang S, Liu PY, Zhao TC. "Irisin deficiency exacerbates diet-induced insulin resistance and cardiac dysfunction in type II diabetes in mice." AJP: Cell Physiology, vol. 325, no. 4, 2023, pp. C1085-C1096. |
| Baggett BC, Murphy KR, Sengun E, Mi E, Cao Y, Turan NN, Lu Y, Schofield L, Kim TY, Kabakov AY, Bronk P, Qu Z, Camelliti P, Dubielecka P, Terentyev D, Del Monte F, Choi BR, Sedivy J, Koren G. "Myofibroblast senescence promotes arrhythmogenic remodeling in the aged infarcted rabbit heart." eLife, vol. 12, 2023. |
| Oh A, Pardo M, Rodriguez A, Yu C, Nguyen L, Liang O, Chorzalska A, Dubielecka PM. "NF-κB signaling in neoplastic transition from epithelial to mesenchymal phenotype." Cell communication and signaling : CCS, vol. 21, no. 1, 2023, pp. 291. |
| Petersen M, Chorzalska A, Pardo M, Rodriguez A, Morgan J, Ahsan N, Zhao T, Liang O, Kotula L, Bertone P, Gruppuso PA, Dubielecka PM. "Proximity proteomics reveals role of Abelson interactor 1 in the regulation of TAK1/RIPK1 signaling." Molecular oncology, vol. 17, no. 11, 2023, pp. 2356-2379. |
| Vistica Sampino E, Morgan J, Chorzalska A, Nguyen L, Yu C, Rodriguez A, Pardo M, Bonal D, Liang O, Kim M, De Vito R, Lulla RR, Dubielecka PM. "Comparative flow cytometry-based immunophenotyping analysis of peripheral blood leukocytes before and after fixation with paraformaldehyde." Journal of immunological methods, 2022, pp. 113379. |
| Cohen JT, Danise M, Hinman KD, Neumann BM, Johnson R, Wilson ZS, Chorzalska A, Dubielecka PM, Lefort CT. "Engraftment, Fate, and Function of HoxB8-Conditional Neutrophil Progenitors in the Unconditioned Murine Host." Frontiers in Cell and Developmental Biology, vol. 10, 2022, pp. 840894. |
| Kulthinee S, Wang L, Yano N, Dubielecka PM, Zhang LX, Zhuang S, Qin G, Zhao YT, Eugene Chin Y, Zhao TC. "Irisin Preserves Cardiac Performance and Insulin Sensitivity in Response to Hemorrhage." Pharmaceuticals (Basel, Switzerland), vol. 15, no. 10, 2022. |
| Jeong EM, Pereira M, So EY, Wu KQ, Del Tatto M, Wen S, Dooner MS, Dubielecka PM, Reginato AM, Ventetuolo CE, Quesenberry PJ, Klinger JR, Liang OD. "Targeting RUNX1 as a novel treatment modality for pulmonary arterial hypertension." Cardiovascular research, vol. 118, no. 16, 2022, pp. 3211-3224. |
| Treaba DO, Bonal DM, Chorzalska A, Castillo-Martin M, Oakes A, Pardo M, Petersen M, Schorl C, Hopkins K, Melcher D, Zhao TC, Liang O, So EY, Reagan J, Olszewski AJ, Butera J, Anthony DC, Rintels P, Quesenberry P, Dubielecka PM. "Transcriptomics of acute myeloid leukaemia core bone marrow biopsies reveals distinct therapy response-specific osteo-mesenchymal profiles." British Journal of Haematology, 2022. |
| Zhang, Ling, Wang, Jianguo, Zhao, Yu Tina, Dubielecka, Patrycja, Qin, Gangjian, Zhuang, Shougang, Chin, Eugene Y, Liu, Paul Y, Zhao, Ting C. "Deletion of PRAK Mitigates the Mitochondria Function and Suppresses Insulin Signaling in C2C12 Myoblasts Exposed to High Glucose." Frontiers in Pharmacology, vol. 12, 2021, pp. 698714. |
| Olszewski AJ, Chorzalska AD, Petersen M, Ollila TA, Zayac A, Kurt H, Treaba DO, Reagan JL, Hsu A, Egan PC, Butera J, Niroula R, Vatkevich J, Robison J, Sahin I, Jacob AP, Mullins CD, Dubielecka PM. "Detection of clonotypic DNA in the cerebrospinal fluid as a marker of central nervous system invasion in lymphoma." Blood Advances, vol. 5, no. 24, 2021, pp. 5525-5535. |
| Ollila TA, Kurt H, Waroich J, Vatkevich J, Sturtevant A, Patel NR, Dubielecka PM, Treaba DO, Olszewski AJ. "Genomic subtypes may predict the risk of central nervous system recurrence in diffuse large B-cell lymphoma." Blood, vol. 137, no. 8, 2021, pp. 1120-1124. |
| So EY, Sun C, Wu KQ, Dubielecka PM, Reginato AM, Liang OD. "Inhibition of lipid phosphatase SHIP1 expands myeloid-derived suppressor cells and attenuates rheumatoid arthritis in mice." AJP: Cell Physiology, vol. 321, no. 3, 2021, pp. C569-C584. |
| Pando A, Fast L, Dubielecka PM, Chorzalska A, Wen S, Reagan J. "Murine Leukemia-Derived Extracellular Vesicles Elicit Antitumor Immune Response." Journal of blood medicine, vol. 12, 2021, pp. 277-285. |
| Yano N, Zhang L, Wei D, Dubielecka PM, Wei L, Zhuang S, Zhu P, Qin G, Liu PY, Chin YE, Zhao TC. "Irisin counteracts high glucose and fatty acid-induced cytotoxicity by preserving the AMPK-insulin receptor signaling axis in C2C12 myoblasts." AJP: Endocrinology and Metabolism, vol. 318, no. 5, 2020, pp. E791-E805. |
| Wang J, Zhao YT, Zhang L, Dubielecka PM, Zhuang S, Qin G, Chin YE, Zhang S, Zhao TC. "Irisin Improves Myocardial Performance and Attenuates Insulin Resistance in Spontaneous Mutation (Leprdb ) Mice." Frontiers in Pharmacology, vol. 11, 2020, pp. 769. |
| So EY, Sun C, Wu KQ, Driesman A, Leggett S, Isaac M, Spangler T, Dubielecka-Szczerba PM, Reginato AM, Liang OD. "Lipid phosphatase SHIP-1 regulates chondrocyte hypertrophy and skeletal development." Journal of cellular physiology, vol. 235, no. 2, 2020, pp. 1425-1437. |
| So EY, Jeong EM, Wu KQ, Dubielecka PM, Reginato AM, Quesenberry PJ, Liang OD. "Sexual dimorphism in aging hematopoiesis: an earlier decline of hematopoietic stem and progenitor cells in male than female mice." Aging, vol. 12, no. 24, 2020, pp. 25939-25955. |
| Olszewski AJ, Chorzalska AD, Kim AS, Quesenberry PJ, Lopresti ML, Fenton MA, Reagan JL, Butera JN, Sahin I, Hamel C, Robison J, Petersen M, Dubielecka PM. "Clonal haematopoiesis of indeterminate potential among cancer survivors exposed to myelotoxic chemotherapy." British Journal of Haematology, vol. 186, no. 3, 2019, pp. e31-e35. |
| Zhao YT, Wang J, Yano N, Zhang LX, Wang H, Zhang S, Qin G, Dubielecka PM, Zhuang S, Liu PY, Chin YE, Zhao TC. "Irisin promotes cardiac progenitor cell-induced myocardial repair and functional improvement in infarcted heart." Journal of cellular physiology, vol. 234, no. 2, 2019, pp. 1671-1681. |
| So EY, Sun C, Reginato AM, Dubielecka PM, Ouchi T, Liang OD. "Loss of lipid phosphatase SHIP1 promotes macrophage differentiation through suppression of dendritic cell differentiation." Cancer Biology & Therapy, vol. 20, no. 2, 2019, pp. 201-211. |
| Zhao YT, Du J, Yano N, Wang H, Wang J, Dubielecka PM, Qin G, Zhang LX, Zhuang S, Liu PY, Chin YE, Zhao TC. "p38-Regulated/activated protein kinase plays a pivotal role in protecting heart against ischemia-reperfusion injury and preserving cardiac performance." AJP: Cell Physiology, vol. 317, no. 3, 2019, pp. C525-C533. |
| Chorzalska A, Morgan J, Ahsan N, Treaba DO, Olszewski AJ, Petersen M, Kingston N, Cheng Y, Lombardo K, Schorl C, Yu X, Zini R, Pacilli A, Tepper A, Coburn J, Hryniewicz-Jankowska A, Zhao TC, Oancea E, Reagan JL, Liang O, Kotula L, Quesenberry PJ, Gruppuso PA, Manfredini R, Vannucchi AM, Dubielecka PM. "Bone marrow-specific loss of ABI1 induces myeloproliferative neoplasm with features resembling human myelofibrosis." Blood, vol. 132, no. 19, 2018, pp. 2053-2066. |
| Zhang L, Wang H, Zhao Y, Wang J, Dubielecka PM, Zhuang S, Qin G, Chin YE, Kao RL, Zhao TC. "Myocyte-specific overexpressing HDAC4 promotes myocardial ischemia/reperfusion injury." Molecular Medicine, vol. 24, no. 1, 2018, pp. 37. |
| Chorzalska A, Ahsan N, Rao RSP, Roder K, Yu X, Morgan J, Tepper A, Hines S, Zhang P, Treaba DO, Zhao TC, Olszewski AJ, Reagan JL, Liang O, Gruppuso PA, Dubielecka PM. "Overexpression of Tpl2 is linked to imatinib resistance and activation of MEK-ERK and NF-κB pathways in a model of chronic myeloid leukemia." Molecular oncology, vol. 12, no. 5, 2018, pp. 630-647. |
| Zhang LX, Du J, Zhao YT, Wang J, Zhang S, Dubielecka PM, Wei L, Zhuang S, Qin G, Chin YE, Zhao TC. "Transgenic overexpression of active HDAC4 in the heart attenuates cardiac function and exacerbates remodeling in infarcted myocardium." Journal of Applied Physiology, vol. 125, no. 6, 2018, pp. 1968-1978. |
| Liang OD, So EY, Egan PC, Goldberg LR, Aliotta JM, Wu KQ, Dubielecka PM, Ventetuolo CE, Reginato AM, Quesenberry PJ, Klinger JR. "Endothelial to haematopoietic transition contributes to pulmonary arterial hypertension." Cardiovascular research, vol. 113, no. 13, 2017, pp. 1560-1573. |
| Wang H, Zhao YT, Zhang S, Dubielecka PM, Du J, Yano N, Chin YE, Zhuang S, Qin G, Zhao TC. "Irisin plays a pivotal role to protect the heart against ischemia and reperfusion injury." Journal of cellular physiology, vol. 232, no. 12, 2017, pp. 3775-3785. |
| Chorzalska A, Kim JF, Roder K, Tepper A, Ahsan N, Rao RSP, Olszewski AJ, Yu X, Terentyev D, Morgan J, Treaba DO, Zhao TC, Liang O, Gruppuso PA, Dubielecka PM. "Long-term exposure to imatinib mesylate downregulates Hippo pathway and activates YAP in a model of chronic myelogenous leukemia." Stem Cells and Development, vol. 26, no. 9, 2017, pp. 656-677. |
| Wu KQ, Muratore CS, So EY, Sun C, Dubielecka PM, Reginato AM, Liang OD. "M1 Macrophage-Induced Endothelial-to-Mesenchymal Transition Promotes Infantile Hemangioma Regression." The American Journal of Pathology, vol. 187, no. 9, 2017, pp. 2102-2111. |
| Lim SH, Dubielecka PM, Raghunathan VM. "Molecular targeting in acute myeloid leukemia." Journal of Translational Medicine, vol. 15, no. 1, 2017, pp. 183. |
| Zhang L, Du J, Yano N, Wang H, Zhao YT, Dubielecka PM, Zhuang S, Chin YE, Qin G, Zhao TC. "Sodium Butyrate Protects -Against High Fat Diet-Induced Cardiac Dysfunction and Metabolic Disorders in Type II Diabetic Mice." Journal of cellular biochemistry, vol. 118, no. 8, 2017, pp. 2395-2408. |
| Du J, Zhang L, Wang Z, Yano N, Zhao YT, Wei L, Dubielecka-Szczerba P, Liu PY, Zhuang S, Qin G, Zhao TC. "Exendin-4 induces myocardial protection through MKK3 and Akt-1 in infarcted hearts." AJP: Cell Physiology, vol. 310, no. 4, 2016, pp. C270-83. |
| Michalczyk I, Toporkiewicz M, Dubielecka PM, Chorzalska A, Sikorski AF. "PKC-θ is a negative regulator of TRAIL-induced and FADD-mediated apoptotic spectrin aggregation." Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society, vol. 54, no. 1, 2016, pp. 1-13. |
| Chorzalska A, Salloum I, Shafqat H, Khan S, Marjon P, Treaba D, Schorl C, Morgan J, Bryke CR, Falanga V, Zhao TC, Reagan J, Winer E, Olszewski AJ, Al-Homsi AS, Kouttab N, Dubielecka PM. "Low expression of Abelson interactor-1 is linked to acquired drug resistance in Bcr-Abl-induced leukemia." Leukemia, vol. 28, no. 11, 2014, pp. 2165-77. |
| Chorzalska A, Dubielecka PM. "New Abelson interactor-1 (Abi-1)-driven mechanism of acquired drug resistance." Leukemia Supp, vol. 3, no. Suppl 1, 2014, pp. S7-8. |
| Bartos A, Dubielecka PM. "The emerging role of Bcr-Abl-induced cystoskeletal remodeling in systemic persistence of leukemic stem cells." Current Drug Delivery, vol. 11, no. 5, 2014, pp. 582-91. |
| Toporkiewicz, Monika, Grzybek, Michał, Meissner, Justyna, Michalczyk, Izabela, Dubielecka, Patrycja M., Korycka, Justyna, Seweryn, Ewa, Sikorski, Aleksander F. "Release of an ~55kDa fragment containing the actin-binding domain of β-spectrin by caspase-8 during FND-induced apoptosis depends on the presence of protein 4.1." Archives of Biochemistry and Biophysics, vol. 535, no. 2, 2013, pp. 205-213. |
| Hossain, S., Dubielecka, P. M., Sikorski, A. F., Birge, R. B., Kotula, L. "Crk and ABI1: binary molecular switches that regulate abl tyrosine kinase and signaling to the cytoskeleton." Genes & Cancer, vol. 3, no. 5-6, 2012, pp. 402-13. |
| Xiong X, Chorzalska A, Dubielecka PM, White JR, Vedvyas Y, Hedvat CV, Haimovitz-Friedman A, Koutcher JA, Reimand J, Bader GD, Sawicki JA, Kotula L. "Disruption of Abi1/Hssh3bp1 expression induces prostatic intraepithelial neoplasia in the conditional Abi1/Hssh3bp1 KO mice." Oncogenesis, vol. 1, no. 9, 2012, pp. e26. |
| Zhang L, Chen B, Zhao Y, Dubielecka PM, Wei L, Qin GJ, Chin YE, Wang Y, Zhao TC. "Inhibition of histone deacetylase-induced myocardial repair is mediated by c-kit in infarcted hearts." Journal of Biological Chemistry, vol. 287, no. 47, 2012, pp. 39338-48. |
| Michalczyk I, Sikorski AF, Kotula L, Junghans RP, Dubielecka PM. "The emerging role of protein kinase Cθ in cytoskeletal signaling." Journal of Leukocyte Biology, vol. 93, no. 3, 2012, pp. 319-327. |
| Dubielecka, P. M., Ladwein, K. I., Xiong, X., Migeotte, I., Chorzalska, A., Anderson, K. V., Sawicki, J. A., Rottner, K., Stradal, T. E., Kotula, L. "Essential role for Abi1 in embryonic survival and WAVE2 complex integrity." Proceedings of the National Academy of Sciences, vol. 108, no. 17, 2011, pp. 7022-7. |
| Dubielecka PM, Hwynn N, Sengun C, Lee S, Lomas-Francis C, Singer C, Fernandez HH, Walker RH. "Two McLeod patients with novel mutations in XK." Journal of the Neurological Sciences, vol. 305, no. 1-2, 2011, pp. 160-4. |
| Dubielecka, Patrycja M., Machida, Kazuya, Xiong, Xiaoling, Hossain, Sajjad, Ogiue-Ikeda, Mari, Carrera, Ana C., Mayer, Bruce J., Kotula, Leszek. "Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells." FEBS Letters, vol. 584, no. 15, 2010, pp. 3279-86. |
| Dubielecka, Patrycja M., Grzybek, Michał, Kolondra, Adam, Jaźwiec, Bożena, Draga, Anna, Aleksandrowicz, Paulina, Kołodziejczyk, Monika, Serwotka, Anna, Dolińska-Krajewska, Barbara, Warchoł, Jerzy, Kuliczkowski, Kazimierz, Sikorski, Aleksander F. "Aggregation of spectrin and PKCtheta is an early hallmark of fludarabine/mitoxantrone/dexamethasone-induced apoptosis in Jurkat T and HL60 cells." Molecular and Cellular Biochemistry, vol. 339, no. 1-2, 2010, pp. 63-77. |
| Dubielecka PM, Cui P, Xiong X, Hossain S, Heck S, Angelov L, Kotula L. "Differential regulation of macropinocytosis by Abi1/Hssh3bp1 isoforms." PLoS ONE, vol. 5, no. 5, 2010, pp. e10430. |
| Bok E, Plazuk E, Hryniewicz-Jankowska A, Chorzalska A, Szmaj A, Dubielecka PM, Stebelska K, Diakowski W, Lisowski M, Langner M, Sikorski AF. "Lipid-binding role of βII-spectrin ankyrin-binding domain." Cell Biology International, vol. 31, no. 12, 2007, pp. 1482-1494. |
| Dubielecka, Patrycja M., Trusz, Anna, Diakowski, Witold, Grzybek, Michał, Chorzalska, Anna, Jaźwiec, Bozena, Lisowski, Marek, Jezierski, Adam, Sikorski, Aleksander F. "Mitoxantrone changes spectrin-aminophospholipid interactions." Molecular Membrane Biology, vol. 23, no. 3, 2006, pp. 235-243. |
| Dubielecka PM, Jaźwiec B, Potoczek S, Wróbel T, Miłoszewska J, Haus O, Kuliczkowski K, Sikorski AF. "Changes in spectrin organisation in leukaemic and lymphoid cells upon chemotherapy." Biochemical pharmacology, vol. 69, no. 1, 2005, pp. 73-85. |
| Grzybek M, Kozubek A, Dubielecka P, Sikorski AF. "Rafts--the current picture." Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society, vol. 43, no. 1, 2005, pp. 3-10. |
| Stebelska K, Dubielecka PM, Sikorski AF. "The Effect of PS Content on the Ability of Natural Membranes to Fuse with Positively Charged Liposomes and Lipoplexes." J Membrane Biol, vol. 206, no. 3, 2005, pp. 203-214. |
| Hryniewicz-Jankowska A, Bok E, Dubielecka P, Chorzalska A, Diakowski W, Jezierski A, Lisowski M, Sikorski AF. "Mapping of an ankyrin-sensitive, phosphatidylethanolamine/phosphatidylcholine mono- and bi-layer binding site in erythroid beta-spectrin." Biochem. J., vol. 382, no. Pt 2, 2004, pp. 677-85. |
| Dubielecka PM, Stebelska K, Jaźwiec B, Sikorski AF. "Cystocyte and lymphocyte derived fusomes/spectrosomes: analogies and differences: a mini-review." Cellular & molecular biology letters, vol. 8, no. 1, 2003, pp. 221-9. |
| Zhao H, Dubielecka PM, Söderlund T, Kinnunen PK. "Interactions of adriamycin, cytochrome c, and serum albumin with lipid monolayers containing poly(ethylene glycol)-ceramide." Biophysical Journal, vol. 83, no. 2, 2002, pp. 954-67. |
| Dubielecka P, Potoczek S, Jazwiec B, Miloszewska J, Kuliczkowski K, Sikorski AF. "The Effect Of Chemotherapy With Fluodarabine/Mitoxantrone/Dexamethasone On The Distribution Of Spectrin In Lymphocytes Of Non-Hodgkin Lymphoma Patients." Cellular & molecular biology letters, vol. 6, no. 2, 2001, pp. 200. |
Advancing age is the single most significant risk factor for development of majority of cancers, including hematological malignancies. As the aging of human race is accelerating and associated health burden expands, it is critical to uncover molecular underpinnings of age-related neoplasms in order to develop efficient therapeutic strategies. The research in my laboratory focuses on interrogating the effects of age-related chronic inflammation on the malignant transformation of hematopoietic stem cells leading to development of blood neoplasms. We are interested in outlining how aging microenvironment affects homeostasis of hematopoietic stem cells and blood producing system as a whole. Reciprocally, we are also interested in assessing how malignant stem cells affect and harness microenvironment to support their systemic retention and blood cancer recurrence. Our ultimate goal is though our findings inform new therapeutic strategies to eradicate disease initiating malignant hematopoietic stem cells.
NIH/NCI R01CA218079
NIH/NIGMS P20GM119943
NIH/NIGMS P30GM145500
Legorreta Cancer Center
Rhode Island Foundation
American Society of Hematology
| Year | Degree | Institution |
|---|---|---|
| 2005 | PhD | University of Wroclaw |
| 2001 | MSc | University of Wroclaw |
| 1999 | BS | University of Wroclaw |
Polish Ministry of Education Award 3P04C09725 PhD project "Spectrin in early apoptosis in lymphoid and lymphoblastic cells'.
Socrates/Erasmus Scholarship of EU, Helsinki Biophysics & Biomembrane Group, Department Of Medical Chemistry, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
Socrates/Erasmus Scholarship of EU, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Department of Medical Biology and Genetics, Hradec Kralove, Czech Republic
2016 DEANS Award Brown University
Associate Professor of Medicine at the Alpert Medical School of Brown University
Pathobiology Graduate Program Co-Director
Director of Translational Hematology
| BIOL 1290 - Cancer Biology |
