John Sedivy is recognized for his efforts in mammalian cell genetics, having developed and pioneered methods for gene targeting of somatic cells. In 1995 his laboratory isolated the first viable gene knockout of the c-Myc oncogene, and in 1997 the first homozygous gene knockout in a normal human cell. Since 1998 his research has focused on understanding the biology of aging at the cellular level. These projects currently investigate the epigenetic regulation of cellular senescence, genome-wide surveillance of transposable elements, and the role of c-Myc in aging.
Professor John Sedivy joined the Brown Faculty in 1996 and is a member of the Department of Molecular Biology, Cell Biology and Biochemistry. He obtained his PhD from Harvard in 1985, and subsequently trained with the Nobel Laureate Philip Sharp at the MIT Center for Cancer Research. He started his independent research career at Yale University in 1988.
JOHN SEDIVY, PHD
On The Web:
By knocking out gene p21, research team temporarily thwarts human cells' aging process
Findings about cell division yield new target for cancer drug
Research on biology of aging puts Brown on the map (GSJ of June 25, 2004)
Brown researchers discover important piece of genetic aging puzzle
Aging cells lose their grip on DNA rogues
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