You're searching for faculty members in:
Molecular Pharmacology, Physiology and Biotechnology, Department of

38 matches found.

	Kailash Agarwal Molecular Pharmacology, Physiology and Biotechnology, Department of
	Bahar Bilgen Molecular Pharmacology, Physiology and Biotechnology, Department of Dr. Bahar Bilgen works at the Center for Restorative and Regenerative Medicine at Providence VA Medical Center/Brown University on cartilage tissue engineering using novel cell sources and drug delivery techniques. Engineered cartilage tissues can be used to restore cartilage function after traumatic cartilage injuries or diseases such as arthritis and osteoarthritis.
	Wayne Bowen Molecular Pharmacology, Physiology and Biotechnology, Department of We study sigma receptors, proteins found throughout the body. They bind several classes of psychoactive drugs. Activation of sigma-2 receptors causes programmed cell death (apoptosis). We are trying to understand the underlying mechanisms for this. Because they are highly expressed in cancer cells, we are targeting sigma-2 receptors for development of new antineoplastic agents. Also, antipsychotic drugs such as haloperidol damage neurons via sigma-2 receptors. Blocking sigma-2 receptors might prevent the irreversible motor side effects caused by typical neuroleptic agents.
	Barrett Bready Molecular Pharmacology, Physiology and Biotechnology, Department of
	Shih-hsi Chu Molecular Pharmacology, Physiology and Biotechnology, Department of
	Deborah Ciombor Orthopedics, Department of Molecular Pharmacology, Physiology and Biotechnology, Department of Dr. Deborah McK. Ciombor's research focuses on cell-based tissue engineering to create a transplantable biocomposite cartilage replacement that may be able to restore function lost to trauma or disease. A stem cell population has been identified in joint lining tissues (synovium) that can be differentiated into cartilage cells by exposure to specific sequences of growth factors.
	James Clifton Molecular Pharmacology, Physiology and Biotechnology, Department of
	Eric Darling Molecular Pharmacology, Physiology and Biotechnology, Department of The goal of the Darling lab is to understand the relationship between the biological function of cells and tissues and their micro/nano-scale mechanical properties. We investigate these characteristics via atomic force microscopy, a technique that allows high resolution imaging and force measurements. Recent findings suggest that cells exhibit distinct mechanical biomarkers, which could help identify specific cell types within heterogenous populations (i.e. metastatic cancer cells, stem cells).
	Robert Dowben Molecular Pharmacology, Physiology and Biotechnology, Department of Robert Dowben does research on cell membrane proteins, muscle proteins and muscle diseases.
	Jeannette Downing-Park Molecular Pharmacology, Physiology and Biotechnology, Department of
	Stacia Furtado Molecular Pharmacology, Physiology and Biotechnology, Department of
	Moses Goddard Molecular Pharmacology, Physiology and Biotechnology, Department of
	Leon Goldstein Molecular Pharmacology, Physiology and Biotechnology, Department of Investigation is aimed at elucidating the mechanisms that cells employ in regulating their volume under normal conditions and during osmotic stress. We are examining this question in fish, since many representatives of this group normally encounter wide variations in osmolarity of the external environment and can tolerate marked perturbations in the osmotic pressure of their extracellular fluid.
	Chi-Ming Hai Molecular Pharmacology, Physiology and Biotechnology, Department of Our research is concerned with how mechanical force and deformation modulate airway smooth muscle responsiveness and remodeling. We take an integrative approach to this research area by performing experiments from muscle mechanics to gene expression. • Systems Biology of Inflammatory Gene Expression in Airway Smooth Muscle • Regulation of Podosome Dynamics in Vascular Smooth Muscle Cells
	Edward Hawrot Molecular Pharmacology, Physiology and Biotechnology, Department of We pursue biochemical and pharmacological studies aimed at understanding the fundamental structure-function relationship of nicotinic acetylcholine receptors (nAChRs). We also study the molecular basis for the highly specific recognition of muscle-type nAChRs by certain snake venom-derived toxins classified as alpha-neurotoxins. More recently, we have used homologous recombination techniques to construct a knock-in mouse in which the alpha3 gene encoding one subtype of neuronal nAChRs has been minimally mutated to impart pharmacological sensitivity to the classic nicotinic antagonist, alpha-bungarotoxin. These mice should enable a systematic determination of the role of alpha3-containing nAChRs in behavior and nervous system function.
	Diane Hoffman-Kim Molecular Pharmacology, Physiology and Biotechnology, Department of The goal of the Hoffman-Kim laboratory is to understand axon guidance in complex environments and inform biomaterial and tissue engineering strategies for promoting nerve regeneration. We apply engineering techniques to biological systems in vitro to challenge growing neurons with multiple guidance cues, including diffusible factors, substrate-bound molecules, electrical cues, and topographical surface features.
	Frederic Hoppin Medicine, Department of Molecular Pharmacology, Physiology and Biotechnology, Department of
	Mark Iampietro Molecular Pharmacology, Physiology and Biotechnology, Department of
	Donald Jackson Molecular Pharmacology, Physiology and Biotechnology, Department of The major goal of my research is to understand the physiological mechanisms that adapt animals to stresses such as anoxia, acidosis, and variable temperature. The focus is on ectothermic vertebrates, such as freshwater turtles, that can survive long periods without oxygen and can function over a wide range of body temperatures. Studies are carried out on whole animals, on isolated organs, and on cell preparations. Current research seeks to understand the mechanisms that permit a freshwater turtle to survive prolonged submergence, particularly during its winter hibernation when ice cover prevents breathing.
	Jules Serge Jacob Molecular Pharmacology, Physiology and Biotechnology, Department of
	Conrad Johanson Neurosurgery Molecular Pharmacology, Physiology and Biotechnology, Department of Professor of Clinical Neuroscience (Neurosurgery) Conrad Johanson investigates the transport and permeability roles of the blood-Cerebrospinal Fluid (CSF) interface (choroid plexus) and blood-brain barrier (cerebral capillaries) in regulating the neuronal fluid environment. His research involves models of ischemia, hydrocephalus, and aging to clarify how CSF and brain interstitial fluid homeostatic mechanisms are altered in Alzheimer's disease. The goal is to identify pharmacological strategies for preventing or repairing damage to 'barrier cells' that defend the integrity of brain fluids.
	Julie Kauer Molecular Pharmacology, Physiology and Biotechnology, Department of Neuroscience, Dept. of Clinical My laboratory focuses on understanding molecular mechanisms involved in synaptic plasticity and modulation of neuronal excitability using modern electrophysiological techniques in brain slices. Our work is related to understanding fundamental processes in memory and in drug addiction.
	Min Kim Molecular Pharmacology, Physiology and Biotechnology, Department of
	Michael Lysaght Molecular Pharmacology, Physiology and Biotechnology, Department of Professor Lysaght's area of specialization is the therapeutic application of synthetic membranes and other barrier materials in hemodialysis, apheresis, and tissue engineering. He also studies the complex interplay of technology, economics, and public policy in shaping contemporary and emerging organ-replacement therapies and has recently described this in several influential publications.
	Donald Marsh Molecular Pharmacology, Physiology and Biotechnology, Department of
	John Marshall Molecular Pharmacology, Physiology and Biotechnology, Department of In response to hormonal or synaptic stimulation, excitable cells (including smooth muscle, cardiac muscle, and neurons) undergo a diversity of changes in their electrical properties. My lab is studying the trafficking and localization of glutamate receptors and calcium channels to synapses, and their modulation by protein kinases.
	Edith Mathiowitz Molecular Pharmacology, Physiology and Biotechnology, Department of Research in our laboratory focuses on the polymer science-medicine interface. Areas of interest include development and modeling of novel drug delivery systems, particularly for the release of insulin and growth factors; designing small-diameter vascular grafts with better compliance; development of novel bioadhesive polymers for oral delivery systems; liquid crystals as smart sensors; the use of nanoparticles as novel therapeutic delivery systems (nanomedicine), tissue markings, DNA delivery.
	Ralph Miech Molecular Pharmacology, Physiology and Biotechnology, Department of Mechanism of action of antiplatelet agents and biological response modifiers in immunopharmacology.
	Jeffrey Morgan Molecular Pharmacology, Physiology and Biotechnology, Department of Research in the lab is focused on understanding the molecular and cellular biology of the skin with an eye towards new therapeutic approaches to wound healing, the repair of the skin and the improvement in the performance of percutaneous medical devices. We are also working on novel devices containing living cells to profile gene expression, monitor the toxicity of nanomaterials, and to study the dynamics of the cell adhesion process.
	Elena Oancea Molecular Pharmacology, Physiology and Biotechnology, Department of The focus of my laboratory is in understanding signal transduction events using fluorescent microscopy in living cells. My lab is equipped with a state-of-the-art two-color TIRF microscope, which we will use to study UV-induced pigmentation in human skin and melanoma behavior. To visualize signal transduction events, we design and generate novel fluorescent probes using molecular biology techniques, which give us a unique angle in answering biologically relevant questions.
	Mahasin Osman Molecular Pharmacology, Physiology and Biotechnology, Department of
	Wolfgang Peti Molecular Pharmacology, Physiology and Biotechnology, Department of Chemistry, Department of The focus of my research group is to understand the molecular basis of PP1 regulation. We combine the information derived from biomolecular NMR spectroscopy, X-ray crystallography, and additional biophysical techniques, such as ITC, DSC, Biacore, and CD spectroscopy to undertsand how PP1 is targeted, regulated and inhibited in vitro and in vivo. Furthermore, my research group is pursuing the production and the structure elucidation of membrane proteins and protein essential for the formation of bacterial biofilms.
	Morris Leon Povar Molecular Pharmacology, Physiology and Biotechnology, Department of
	Tanya Sanders Molecular Pharmacology, Physiology and Biotechnology, Department of
	Andrea Jeanne Sobieraj Molecular Pharmacology, Physiology and Biotechnology, Department of
	Babette Taylor Stewart Molecular Pharmacology, Physiology and Biotechnology, Department of
	Beth Anne Zielinski Molecular Pharmacology, Physiology and Biotechnology, Department of
	Anita L. Zimmerman Molecular Pharmacology, Physiology and Biotechnology, Department of Our research is in molecular and cellular aspects of the nervous system, with an emphasis on ion channels and the early stages of vision in rods and cones. An ion channel is a membrane protein with an internal pore that opens in response to chemical and electrical signals, allowing passage of specific ions such as sodium and calcium. Ion channels are critically involved in functions as diverse as nerve impulses in the brain, the beating of the heart, visual perception, muscle contraction, learning and memory, hormone secretion and embryonic development. They are also the targets of many drugs, such as those used to treat pain and heart disease. Genetic defects in ion channels can cause devastating diseases, such as cystic fibrosis.