CURRICULUM VITAE Edward K.S. Chien, M.D. Revised 3/30/2005 BUSINESS ADDRESS: 101 Dudley St Providence, Rhode Island, 02905 Phone: (401)-274-1122 ext 2353 Fax: (401)-453-7622 Email: echien@wihri.org EDUCATION 1980-1984 University of Illinois @ Urbana-Champaign, Illinois. Chemical Engineering, Bachelor of Science, May 1984. 1984-1988 University of Illinois @ Chicago, Abraham Lincoln College of Medicine. 840 S. Wood St., Chicago, Illinois 60612. Doctor of Medicine, Medical Degree, June 1988. POSTGRADUATE TRAINING 1988-1989 Internship Obstetrics and Gynecology, Department of Obstetrics and Gynecology, University of Illinois Hospital, 840 S. Wood St., Chicago, Illinois 60612. July 1988- June 1989 1989-1992 Residency Obstetrics and Gynecology, Department of Obstetrics and Gynecology, University of Michigan Medical Center, 1200 E. Medical Center Dr., Ann Arbor, Michigan, 48109. July 1989-June 1992. 1992-1994 Fellowship Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Chicago Hospitals, 5841 S. Maryland Ave., Chicago, Illinois, 60637. July 1992-June 1994. 1995 Postdoctoral Fellow, Dept of Pharmacology and Physiology, Professor Richard Miller, University of Chicago, 5841 S. Maryland Ave., Chicago, Illinois, 60637. Jan-June 1995. 1994-1998 Postdoctoral Fellow, Dept of Molecular Biology and Biochemistry, Professor Graeme I Bell (Louis Block Professor), Howard Hughes Medical Institute, University of Chicago, 5841 S. Maryland Ave., Chicago, Illinois, 60637. July 1994-Dec 1994 & July 1995-June1998. 1999 Optical Microscopy and Imaging in the Biomedical Sciences. Professor Colin Izzard Instructor, Marine Biological Laboratory, Woods Hole, MA. October 1999. AWARDS AND HONORS 1981 Alpha Lambda Delta- University of Illinois, June 1981. 1981 Phi Eta Sigma-University of Illinois, June 1981. 1982-1984 Dow Chemical Company Scholarship- University of Illinois. 1988 Tau Beta Pi- University of Illinois, May 1988. 1993 Chicago Lying-In Board of Directors' Babies Alumni Fellowship Award University of Chicago, April 1993. 1994 Chicago Lying-In Board of Directors' Babies Alumni Fellowship Award University of Chicago, April 1994. 1995 NICHD, March of Dimes Fellow, July 1995. 1996 Society for Gynecologic Investigation President's Presenter Award Identification of genes gestationally regulated in rat myometrium by differential mRNA display. March 1996. 1998 Young Investigator Award- Perinatal Research Society, October 1998. 2001 Golden Apple Award- University of Chicago, Department of Obstetrics and Gynecology Resident Teaching Award. June 2001. 2001 Society for Gynecologic Investigation-Student Research Stipend Award March 2001. 2001 Society of Maternal Fetal Medicine 21st Annual Meeting Best Poster Award-Prothrombinase expression in the pregnant rat uterus. Jan 2001. 2005 Ross Pharmaceuticals/New England Perinatal Society Research Award: Electron Microscope Examination of Cervical Microstructure After PGE2-induced Ripening in the Rat Suggests a Primary Role for Proteoglycanases. New England Perinatal Society Manchester, NH. March 2005. LICENSURE / CERTIFICATION 1989 National Board of Medical Examiners, Diplomat. 1992 Federal DEA# BC-3351715, Exp 7/31/2007. 1990-1993 Michigan Medical License #4301054968, inactive. 1992 Illinois Medical License #036-084439, Exp 7/31/2005. 1995 Minnesota Medical License #38997, Exp 5/31/2005. 1996 American Board of Obstetrics and Gynecology, Board Certified. 1997 Special Certification in Maternal Fetal Medicine. ABOG. 2002-2011 American Board of Obstetrics and Gynecology & MFM Recertification Exam June 2002, Exp 6/2011. 2002 Vermont Medical License #042-0010353, Exp 11/30/2006. 2004 South Dakota License (LT-2040 Jun-Aug) / 5479 Exp 3/2006. 2004 Rhode Island Medical License #11537, Exp 6/30/2006. 2004 Massachusetts Medical License #222688, Exp 5/9/2005. 2004 Massachusetts Controlled Sub MC0567365A, Exp 5/9/2005. ACADEMIC APPOINTMENTS 1992-1996 Instructor, Department of Obstetrics and Gynecology, Section of Maternal Fetal Medicine, University of Chicago, 5841 S. Maryland Ave, Chicago, IL 60637. July 1992-June 1996. 1996-2002 Assistant Professor, Department of Obstetrics and Gynecology, Section of Maternal Fetal Medicine, University of Chicago 5841 S. Maryland Ave, Chicago, IL 60637. July 1996-Feb 2002. 2002-2004 Associate Professor, Department of Obstetrics and Gynecology, Section of Maternal Fetal Medicine, University of Vermont 89 Beaumont Dr., Burlington, VT 05405 . Feb 2002-Aug 2004. 2004-Present Assistant Professor, Department of Obstetrics and Gynecology Section of Maternal Fetal Medicine, Women and Infants Hospital, Brown University, 101 Dudley St., Providence, RI 02906. Aug 2004. HOSPITAL APPOINTMENTS 1992-2002 University of Chicago Hospitals, Chicago, IL. July 1992-Feb 2002. 2002-2004 Fletcher Allen Health Care, Burlington, VT. Feb 2002-Aug 2004. 2004 Avera-McKennon Hospital, Sioux Falls, SD. July 2004-August 2004. 2004-present Women and Infants Hospital, Providence, RI (Care New England). Aug 2004-Present. 2005-present Rhode Island Hospital, Providence, RI (Lifespan). May 2005-Present. 2005-present South County Hospital, Wakefield, RI. Feb 2005-Present. 2005-present Charlton Memorial Hospital, Fall River, MA (Southcoast Hosp. Group) Feb 2005-Present. OTHER APPOINTMENTS AND PROFESSIONAL EXPERIENCE 1982-1983 Summer Intern- Dow Chemical Company, Midland, Michigan, Summer 1982,1983. 1984 Chemist- Pierce Chemical Company, Rockford, Illinois. 1984. 1985 Teaching Assistant- Neuroanatomy, University of Illinois, College of Medicine. 1987-1988 Externship, Department of Obstetrics and Gynecology, Evanston Hospital, Evanston, Illinois. 1990-1992 Physician, Obstetrics and Gynecology, Whitmore Lake Health Clinic, Whitmore Lake, Michigan. 1992-1995 House Physician, Dept of Obstetrics and Gynecology, Alexian Brothers Medical Center, Elk Grove Village, Illinois. 1996-1997 Physician, Minnesota Perinatal Associates, Department of Obstetrics and Gynecology, Abbott-Northwestern Hospital, 800 E 28th St., Minneapolis, MN 48109. 11/96-12/97 2004 Vista Staffing Solutions-Locum Tenums Avera McKennon Medical Center Maternal Fetal Medicine, Sioux Falls, SD July-Aug, 2004 HOSPITAL COMMITTEES 1999-2001 Perinatal Network Outreach Review, Hinsdale Hospital, University of Chicago Representative. Chairperson Atef Moawad. 1999 Member Search Committee for Division Director of Ultrasound, Dept of Ob/Gyn. University of Chicago. Chairperson Mark Phillippe. 2001-2002 Perinatal Network Outreach Review, Weiss Hospital, University of Chicago Representative. Chairperson Atef Moawad. 2003 Search Committee Genetics Hire, Dept of Ob/Gyn. University of Vermont. Chairperson Ira Bernstein. UNIVERSITY COMMITTEES 1999-2002 Member Institutional Review Board, University of Chicago. Chairperson Professor Moss. 2002 Maternal Fetal Medicine Assistant Fellowship Director. Dept of Ob/Gyn. University of Vermont. Director Eleanor Capeless. Feb 2002-June 2003. 2003 Maternal Fetal Medicine Fellowship Director. Dept of Ob/Gyn. University of Vermont. Director Eleanor Capeless. July 2003-Feb 2004. 2004 Maternal Fetal Medicine Assistant Fellowship Director. Dept of Ob/Gyn. Brown University, Women & Infants Hospital. Director Marshall Carpenter. Aug 2004-June 2005. 2005 Maternal Fetal Medicine Fellowship Director. Dept of Ob/Gyn. Brown University. Women & Infants Hospital. July 2005-present. 2005 Computing Advisory Board. Brown University. Chairperson Ellen Waite-Franzen. Feb 2005-Present. MEMBERSHIPS IN SOCIETIES 1988-1999 Chicago Medical Society 1988-1999 Illinois State Medical Society 1988-1999 American Medical Association 1992-Present Norman Miller Society, University of Michigan. 1993-Present American Institute of Ultrasound in Medicine. 1993-Present American Association for the Advancement of Science. 1995-2002 Chicago Area Perinatal Society. 1996-Present Fellow, The American College of Obstetricians and Gynecologists, Junior Fellow 1989-1996. 1998-Present Member, Federation of American Societies for Experimental Biology. 1998-Present Member, American Society of Cell Biology. 1998-Present Member, Society of Maternal Fetal Medicine, Associate Member 1995-1998. 1999-Present Member, International Society of Ultrasound in Obstetrics and Gynecology. 2002-2005 Member, Vermont Medical Society. 2003-Present Member, Society for Gynecologic Investigation, Associate Member 1997-2003. 2004-Present Member, Perinatal Research Society, Oct 2004. EX-OFFICIO REVIEWER 1997-present Reviewer, American Journal of Obstetrics and Gynecology. 1998-present Reviewer, Obstetrics and Gynecology 1999 External Reviewer, University of Illinois Campus Research Board 2001-present Reviewer, Journal of the Society for Gynecologic Investigation 2001-present Reviewer, Journal of Maternal Fetal Medicine 2002-present Reviewer, Biology of Reproduction 2002 Reviewer, Canadian Journal of Physiology and Pharmacology 2003 Reviewer, Gynecologic and Obstetric Investigation 2004 Reviewer, Pennsylvania Department of Health Grant Program BIBLIOGRAPHY Original Publications In Peer Reviewed Journals: 1. Phillippe M, Chien EK: Potassium chloride effects on the hormonal signal transduction mechanisms underlying phasic myometrial contractions. Journal of Endocrinology 146:485-493, 1995. 2. Phillippe M, Chien EK, Freij M, Saunders T: Mechanisms underlying ionomycin stimulated phasic myometrial contractions. Am J Physiol. 269 (Endocrinol. Metab. 32): E779-E785, 1995. 3. Chien EK, Phillippe M: Mechanisms underlying Bay K 8644 stimulated phasic myometrial contractions. J Soc Gynecol Invest 3:106-112, 1996. 4. Chien EK, Tokuyama Y, Rouard M, Phillippe M, Bell GI: Identification of genes gestationally regulated in rat myometrium by differential mRNA display. Am J Obstet Gynecol 177:645-52, 1997. 5. Chien EK, Hara M, Rouard M, Yano H, Phillippe M, Polonsky KS, Bell GI: Increase in serum leptin and uterine leptin receptor messenger RNA levels during pregnancy in rats. Biochem Biophys Res Comm 237(20):476-80, 1997. 6. Loy G, Lin C-C, Chien EK, Kim JH, Chiang L-M: Cerebral and umbilical vascular resistance response to vibroacoustic stimulation in growth restricted fetuses. Obstet Gynecol 90:947-52,1997. 7. Chien EK, Zhang Y-H, Furuta H, and Hara M. Tissue distribution of KATP-sensitive potassium channels in reproductive rodent tissue. Am J Obstet Gynecol 180:1121-6, 1999. 8. Rychlik DF, Chien EK, Wolff D, Phillippe S, Phillippe M. Cloning and tissue espression of the tissue prothrombinase Fgl-2 in the Spargue Dawley Rat. J Soc Gynecol Invest. 10:67-73, 2003. 9. Chien EK, Kim TT, Wolff DA, Bieber E, and Phillippe M. Protease activated receptor (PAR) isoform expression in pregnant and nonpregnant rat myometrial tissue. J Soc Gynecol Invest. 10:460-68, 2003. 10. Chien EK MacGregor C. Expression and Regulation of the Rat Prostaglandin E2 Receptor Type 4 (EP4) in Pregnant Cervical Tissue. Am J Obstet Gynecol 189:1499-1508, 2003. 11. Elovitz MA, Wang Z, Chien EK, Rychlik D, Phillippe M. A new model for inflammation-induced preterm birth: the role of platelet activating factor and toll-like receptor-4. Am J Pathol 163:2103-2111, 2003. 12. Clark K, Viscomi C, Lowell J, Chien EK. Nitroglycerin for uterine relaxation to establish a fetal airway (EXIT procedure). Obstet Gynecol, 103:1113-5, 2004. 13. Chien EK, Ji H, Feltovich H, Clark K. Expression of MMP-3 in the Rat Cervix during Pregnancy and in Response to Prostaglandin E2. Am J Obstet Gynecol, 192:309-17, 2005. 14. Feltovich H, Ji H, Janowski J, Delance NC, Moran CC, Chien EK. Effects of Selective and Non-Selective PGE2 Receptor Agonists on Cervical Tensile Strength and Collagen Organization and Microstructure in the Pregnant Rat at Term. Am J Obstet Gynecol. 192:753-760, 2005. 15. Dixon ME, Chien EK, Osol G,Callas PW, Bonney EA, Failure of Decidual Arteriolar Remodeling in the CBA/J x DBA/2 Murine Model of Recurrent Pregnancy Loss is Linked to Increased Expression of Tissue Inhibitor of Metalloproteinase 2 (TIMP-2). In Press Am J Obstet Gynecol. March 2005. 16. Clark K, Ji H, Feltovich H, Janowski J, Carroll C, and Chien EK. Mifepristone Induced Cervical Ripening: Structural, Biomechanical, and Molecular Events. In Press Am J Obstet Gynecol. Oct 2005. Other Peer-Reviewed Publications: 1. Phillippe M, Chien EK. Intracellular signaling and phasic myometrial contractions. J Soc Gynecol Invest. 5:169-177, 1998. Books And Book Chapters: Other Non-Peer Reviewed Publications: 1. Chien EK. In the beginning: A young Investigator's Perspective. In: Randolph JF (ed): Research in the Academic Health Center of the Future. Ann Arbor, MI, 1999. Publications Submitted Or In Preparation Abstracts: 1. Phillippe M, Chien EK, Freij M, Saunders T. Effects of extracellular calcium influx on phasic contractile activity of rat myometrial tissue. Society of Gynecologic Investigation, 41st Annual Meeting, Chicago, IL, March 1994, #P432. 2. Phillippe M, Chien EK, Saunders T. The mechanisms underlying potassium chloride stimulated phasic myometrial contractions. Society of Perinatal Obstetricians, Las Vegas, Nevada, Am J Obstet Gynecol 170:#358, 1994. 3. Chien EK, Phillippe M, Protein kinase C activity in gestational myometrium of the rat. American Society of Cell Biology, San Francisco CA, Dec 1994, #858. 4. Chien EK, Loy G, Timing of delivery in twin gestation. Society of Perinatal Obstetricians, Atlanta GA, Am J Obstet Gynecol 172:#106, 1995. 5. Chien EK, Saunders T, Phillippe M, Bay K 8644 stimulates the phosphoinositide pathway. Society of Perinatal Obstetricians, Atlanta GA, Am J Obstet Gynecol 172:#594, 1995. 6. Lee CL, Bindokas VP, Chien EK, Ghadge GD, Roos RR, Miller RJ. Glutamate receptor-mediated increases in intracellular calcium and superoxide production in rat spinal cords. Society for Neuroscience Annual Meeting, Nov 1995. 7. Loy G, Chien EK, Kim JS, Chiang L-M, Lin C-C. Ratio of cerebrovascular to umbilical vascular resistance in fetal growth retardation after vibroacoustic stimulation. American Institute of Ultrasound in Medicine Annual Meeting, March 1996, #0991. 8. Chien EK, Tokuyama Y, Phillippe M. Identification of genes gestationally regulated in rat myometrium by differential mRNA display. Society of Gynecological Investigation, Philadelphia PA, 43rd Annual Meeting, J Soc Gynecol Invest 3:341A, 1996. 9. Colombo D, Chien EK, Sabbagha R, Loy G. The determination of discordance in twin gestations by evaluating estimated fetal weight with different formulae: a retrospective analysis. Society of Perinatal Obstetricians Annual Meeting, Annaheim CA, Am J Obstet Gynecol 176:S75, 1997. 10. Chien EK, Hara M, Rouard M, Yano H, Phillippe M, Polonsky KS, Leptin and leptin receptor expression during pregnancy in the rat. American Society of Cell Biology, Washington D.C., Dec 1997. 11. Chien EK, Hara M, Schilling JR, Phillippe M. Characterization of a novel gene differentially expressed in rat gestational myometrium. Society of Perinatal Obstetricians. Miama FL, Am J Obstet Gynecol 178:S34, 1998. 12. Chien EK, Schilling JR, Zhang Y-H, Phillippe M. Characterization of RPU0101CC, a novel gene expressed in rat gestational myometrium. Society for Gynecologic Investigation, Atlanta GA, J Soc Gynecol Invest 5:179A, 1998. 13. Chien EK, Zhang Y-H, and Hara M. Tissue distribution of KATP-sensitive potassium channels in reproductive rodent tissue. Society for Maternal Fetal Medicine Annual Meeting, San Francisco CA, Am J Obstet Gynecol 180:S121, 1999. 14. Chien EK, Protein expression and cellular localization of the gestationally regulated myometrial gene RPU0101CC. Society for Gynecologic Investigation Annual Meeting, Atlanta GA, J Soc Gynecol Invest 6:228A, 1999. 15. Chien EK, Identifying gestationally regulated genes by cDNA array hybridization. Society for Gynecologic Investigation Annual Meeting, Atlanta GA, J Soc Gynecol Invest 6:228-229A, 1999. 16. Chien EK, Minhaj M, Prostaglandin E2 receptor type 2 mRNA expression in pregnant rat myometrial and cervical tissue. American Society of Cell Biology, San Francisco, CA, Mol Biol Cell 11Supp:2264, 2000. 17. Rychlik D, Chien EK, Phillippe M, Prothrombinase (Fgl-2) expression in the Sprague-Dawley Rat. American Society of Cell Biology, San Francisco CA, Mol Biol Cell 11Supp:839, 2000. 18. Rychlik D, Chien EK, Phillippe M, Prothrombinase expression in the pregnant rat uterus. Society for Maternal Fetal Medicine 21st Annual Meeting, Am J Obstet Gynecol 184:S88, 2001. 19. Minhaj M, Mendoza J, Chien EK. Prostaglandin E receptor mRNA expression in pregnant rat myometrial and cervical tissue. Society for Maternal Fetal Medicine 21st Annual Meeting. Reno, NV, Am J Obstet Gynecol 184:S18, 2001. 20. Chien EK, Marietti S, Mendoza J, Phillippe M, Cloning and tissue expression of the rat protease receptor isoforms 3 and 4 (PAR-3, PAR-4). Society for Gynecologic Investigation Annual Meeting, Toronto Canada, March, J Soc Gynecol Invest 8:264A, 2001. 21. Chien EK, Mendoza J. Ptger-ep3 (Prostaglandin E receptor type 3) splice variant , , and  mRNA expression in pregnant rat myometrial and cervical tissue. Society for Gynecologic Investigation Annual Meeting, Toronto Canada, March, J Soc Gynecol Invest 8:132A, 2001. 22. Rychlik D, Chien EK, Thomas L, Phillippe M. Fgl-2 expression in the uterus during the Sprague-Dawley estrus cycle correlates with peak estrogen levels. American Society of Reproductive Medicine Annual Meeting Orlando, FL. Fertil Ster, Oct 2001. 23. Elovitz M, Chien EK, Rychlik D, Phillippe M. A PAF antagonist prevents preterm delivery in a mouse model of inflammatory preterm labor. Society for Maternal Fetal Medicine Annual Meeting, New Orleans, LA. Am J Obstet Gynecol 185:S70, 2002. 24. Elovitz M, Chien EK, Rychlik D, Phillippe M, Platelet activating factor receptor expression in gestational tissues. Society for Maternal Fetal Medicine Annual Meeting, New Orleans, LA. Am J Obstet Gynecol 185:S134, 2002. 25. Chien EK, Mendoza, Identification of the Ptger-ep2 core promoter. Society for Maternal Fetal Medicine Annual Meeting, New Orleans, LA. Am J Obstet Gynecol 185:S227, 2002. 26. MacGregor C, Mendoza J, Chien EK. Genomic structure and transcriptional regulation of the rat prostaglandin E type 4 receptor. Society for Gynecologic Investigation Annual Meeting, LosAngeles, CA.J Soc Gynecol Invest 9:213A, 2002. 27. Chien EK, Minhaj M, Mendoza J. Modulation of cervical prostaglandin E2 (PGE2) receptors during pregnancy. New England Perinatal Research Society Annual Meeting, Falmouth, MA. Oct 2002. 28. Chien EK, Prostaglandin E2 receptor type 2 & 4 expression in the rat cervix during pregnancy. Society of Maternal Fetal Medicine Annual Meeting, SanFrancisco, CA. Am J Obstet Gynecol 187:S172, 2003. 29. Chien EK, Francis R, Mendoza J. Cervical expression of matrix metalloproteinases during the rat pregnancy. Society for Gynecologic Investigation Annual Meeting, Washington, DC, J Soc Gynecol Invest 10:257A, 2003. 30. Chien EK, Mendoza J. Ets transcription factor regulated Ptger-EP2 transcription. American Society for Cell Biology Annual Meeting, SanFrancisco, CA Dec 2003. Mol Biol Cell 14 Supp:2032, 2003 31. Feltovich H, Ji H, Chien EK. PGE2 induced cervical ripening is mediated by the Ptger-Ep4 receptor. Society for Maternal Fetal Medicine Annual Meeting, Am J Obstet Gynecol 189:S202, 2004. 32. Chien EK, Ji H, Clark K, Feltovich H. Expression of matrix metalloproteinase type 3 (MMP3) in the rat cervix during gestation and in response to PGE2. Oral Presentation. Society for Gynecologic Investigation Annual Meeting, Houston, TX, J Soc Gynecol Invest 11:301A, 2004. 33. Phillippe M, Ji H, Chien EK. Phospholipid scramblase 3 expression in pregnant rat myometrium. Society for Gynecologic Investigation Annual Meeting, Houston, TX, J Soc Gynecol Invest 11:80A, 2004. 34. Phillippe M, Ji H, Chien EK. Expression of a second phospholipids scramblase isoform in pregnant rat myometrium. Oral Presentation. Society for Gynecologic Investigation Annual Meeting, Houston, TX, J Soc Gynecol Invest 11:301A, 2004. 35. Clark K, Ji H, Janowski J, Chien EK. The Effects of Mifepristone on Cervical Tensile Strength and Collagen Structure. New England Perinatal Research Society Annual Meeting, Falmouth, MA. Oct 2004 36. Feltovich H, Ji H, Janowski J, Chien EK. The Effects of Selective and Non-Selective PGE2 Receptor Agonists on Cervical Collagen Content. New England Perinatal Research Society Annual Meeting, Falmouth, MA. Oct 2004. 37. Clark KD, Ji H, Janowski J, Carroll C, Bonney E, Chien EK, The Effects of Mifepristone on Cervical Tensile Strength and Collagen Structure. Society of Maternal Fetal Medicine Annual Meeting, Reno, NV, Am J Obstet Gynecol 191:S183, 2005. 38. Feltovich H, Ji, H, Janowski J, Carroll C, Bonney E, Chien EK, EP4 Receptor Activation Produces Quantifiable Decrease in Cervical Collagen Content. Society of Maternal Fetal Medicine Annual Meeting, Reno, NV, Oral, Am J Obstet Gynecol 191:S15, 2005. 39. Feltovich H, Janowski J, DeLance N, Chien EK, Electron Microscope Examination of Cervical Microstructure after PGE2-induced Ripening in the Rat Suggests a Primary Role for Proteoglycanases. Society for Gynecologic Investigation Annual Meeting, J Soc Gynecol Invest 12:128A, 2005. 40. Dwan JB, Feltovich H, Clark K, DeLance N, Chien EK. A Comparison of Mifepristone and Prostaglandin E2 Effect on Collagen Structure. Society for Gynecologic Investigation Annual Meeting, J Soc Gynecol Invest 12:128A, 2005. 41. Russell M, Ji H, Clark K, Chien EK. Cervical Expression of Cathepsin S During Rat Gestation. Society for Gynecologic Investigation Annual Meeting, J Soc Gynecol Invest 12:132A, 2005. 42. Clark K, Ji H, Chien EK. Matrix Metalloproteinase Type 2(MMP-2) Expression in the Pregnant Rat Cervix Following Administration of Mifepristone. Society for Gynecologic Investigation Annual Meeting, J Soc Gynecol Invest 12:129A, 2005. 43. Dixon ME, Chien EK, Osol G, Bonney EB. Increased Expression of Tissue Inhibitor of Metalloproteinase 2 (TIMP-2) is Linked to Failure of Decidual Arteriolar Remodeling in the CBA/J x DBA/2 Murine Model of Recurrent Pregnancy Loss. Society for Gynecologic Investigation Annual Meeting, J Soc Gynecol Invest 12:108A, 2005. 44. Feltovich H, Janowski J, DeLance N, Chien EK. Electron Microscope Examination of Cervical Microstructure After PGE2-induced Ripening in the Rat Suggests a Primary Role for Proteoglycanases. New England Perinatal Society, Manchester, NH. March 2005. 45. Ballard-Dwan J, Luks FI, Carr SR, Sorrells DR, Rubin LP, Tracy TF, Gibson SE, Chien EK. Antenatal diagnosis of Treacher Collins syndrome: Use of EXIT to manage severe micrognathia. International Fetal-Medical Surgical Society Annual Meeting, Helsignor Denmark, May 2005. 46. Ji H, House M, Long V, McMillan P, Chien EK. Comparison of Proteoglycan Expression in Rat and Human Cervix using Lectin Histochemistry. Society of Maternal Fetal Medicine Annual Meeting, Miami FL, Feb 2006. Poster Presentation Am J Obstet Gynecol _____ 2006. 47. Rana S, Ji, H, Long V, Chien EK. Aromatizable vs Non-aromatizable Androgens in Cervical Ripening. Society of Maternal Fetal Medicine, Miami FL, Feb 2006. Poster Presentation. Am J Obstet Gynecol _____ 2006. 48. Li L, Ji H, Long V, Monfils P, McMillan P, Chien EK. Evaluation of Gestational Proteoglycan Expression in the Rat Cervix using Lectin Histochemistry. Society for Gynecologic Investigation Annual Meeting, J Soc Gynecol Invest __:___A, 2006. Invited Presentations 1. Grand Rounds, Department of Obstetrics and Gynecology, University of Michigan Medical Center, Ann Arbor, MI, Nov. 19, 1991. Title: Viral Infections in Pregnancy. 2. Paper Day, Department of Obstetrics and Gynecology, University of Michigan Medical Center, Ann Arbor, MI, May 21, 1992. Title: Clinical Use of Lung Maturity Studies. 3. Grand Rounds, Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL, August 6, 1993. Title: Red Cell Alloimmunization. 4. Physicians Standards Group, University of Chicago, Perinatal Network, May 1994. Title: Postdate Pregnancy. 5. Perinatal Network Workshop, University of Chicago Hospitals, June 1994. Title: The use of Ultrasound in Pregnancy. 6. Universal Health Conference, Almaty, Kazakhstan, April 28,1995. Title: Trauma During Pregnancy. 7. Grand Rounds, Department of Obstetrics and Gynecology, University of Chicago, May 1996., Title: Identification of Gestationally-Regulated Genes in Rat Myometrium. 8. RSDP Forum, Society of Gynecologic Investigation, San Diego, CA., March 21, 1997. Title: Identification of Gestationally-Regulated Genes in Rat Myometrium. 9. Invited Lecture. Department of Obstetrics and Gynecology, University of Wisconsin at Madison.November 1997. Title: Identification and characterization of gestationally-regulated genes in rat myometrium identified by messenger RNA differential display. 10. Invited Lecture. University of Michigan Medical Center. Blueprint for Academic Ob/Gyn Departments. November 3, 1998.Title: In the beginning: A young investigators perspective. 11. Invited Lecture. Title: Identification and characterization of a gestationally regulated gene in rat myometrium. Magee Research Institute. University of Pittsburgh, Pittsburgh PA. Research in Progress Conference. 2/16/99. 12. Obstetrics and Gynecology Review Course. Chicago Area Medical Schools. June 10, 1999. Title: Gestational Diabetes. 13. Dilemmas in Prenatal Diagnosis: Management Issues, University of Chicago, April 20, 2001. Title: Aggravating Second Trimester Soft Signs for Down Syndrome. 14. Grand Rounds, Department of Obstetrics and Gynecology, University of Vermont, May 2002. Title: Cervical Ripening: The role and mechanism of prostaglandins. 15. Grand Rounds, Department of Obstetrics and Gynecology, University of Vermont, Nov 2002. Title: The Genetic Ultrasound and Its Application. 16. Postgraduate Course in Obstetrics & Gynecology, University of Vermont September 2003. Title: Mechanism of Preterm Labor and Delivery: Current Concepts. 17. MFM Research Conference, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, LosAngeles, CA, October 2003. Title: Molecular Mechanisms of Cervical Ripening. 18. MFM Research Conference, Department of Obstetrics and Gynecology, Womens and Infants Hospital, Brown Medical School, January 2004. Title: Molecular Mechanisms of Cervical Ripening. 19. Grand Rounds, Department of Obstetrics and Gynecology, University of Chicago, January 2004. Title: Molecular Mechanisms of Cervical Ripening. 20. Grand Rounds, Department of Obstetrics and Gynecology, University of New Mexico, January 2004. Title: Molecular Mechanisms of Cervical Ripening. 21. Chien EK, Ji H, Clark K, Feltovich H. Expression of matrix metalloproteinase type 3 (MMP3) in the rat cervix during gestation and in response to PGE2. Oral Presentation. Society for Gynecologic Investigation Annual Meeting, Houston, TX, March 2004. 22. Feltovich H, Ji, H, Janowski J, Carroll C, Bonney E, Chien EK, EP4 Receptor Activation Produces Quantifiable Decrease in Cervical Collagen Content. Society of Maternal Fetal Medicine Annual Meeting, Reno, NV, Oral, 2005. PAST RESEARCH SUPPORT 1. Co-investigator-Clinical Trial Site "TDx/TDxFLx Fetal Lung Maturity II Assay" Abbott Laboratories, 11/93- 6/94. (Extramural). 2. Co-investigator-PI-PLC Function In Pregnant Rat Myometrium. PHS#1-RO1-HD28506-01A4. No Salary Support. 9/1/94-8/31/97. 3. Principal Investigator-Molecular Biology of Uterine Function: Isolation and Characterization of Gestationally-Regulated Genes. NICHD Reproductive Scientist Development Program. $110,000. FD-R-001114-01.7/1/95-6/30/97. 4. Co-investigator-Cooperative Multicenter Maternal Fetal Medicine Units Network. NICHD. 2% effort. PHS#5-U10-HD27861-06. 4/1/96-3/31/01. 5. Principal Investigator-Molecular Biology of Uterine Function During Pregnancy. NICHD Mentored Clinical Scientist Development Award (K-08). PHS#1-K08-HD01232-01. Awarded 3/1/99-2/28/02. Annual Direct/Total costs (1999-2002) $117,250/$379,455. 6. Co-investigator- Fragile Families and Child Wellbeing Study, Princeton University, Principal Investigator- Nancy Reichman Ph.D. 1999-2002. No direct funds. 7. Principal Investigator-PGE2 Receptor Mediated Cervical Ripening. New Research Initiative Grant, University of Vermont. 9/2002-8/2003. $15,000. 8. Principal Investigator- Cervical Expression and Activity of Matrix Metalloproteinases During Pregnancy. Department of Obstetrics and Gynecology Research Fund, University of Vermont. 10/2002-9/2003. $9,000. 9. Co-investigator- (Phillippe-PI) Thrombin-Stimulated Intrauterine Signaling Pathway. NICHD HD044747-01 Funding period 7/1/03-6/30/8. $250,000/$1,250,000. 20% Effort. 10. Research Advisor- Cervical Expression and Activity of Cathepsins During Pregnancy. Kelley Clark, MFM Fellow; Department of Obstetrics and Gynecology Research Fund, University of Vermont. 10/2003-9/2004. $8,000. 11. Research Advisor-Sonographic Cervical Assessment Using Novel Emerging Methodologies (SCAN'EM): Elastography and Quantitative Backscatter Analysis as Predictors of Cervical Ripening. Helen Feltovich MFM Fellow; Creff Grant Subcontract of General Clinical Research Center, University of Vermont. Principal Investigator-John Evans NIH- M01 RR00109. 12. Mentor-(Feltovich-PI) ACOG/Kenneth Gottesfeld-Charles Hohler Memorial Foundation Research Award in Ultrasound. Funding Period 7/1/05-6/30/05. $10,000. ACTIVE RESEARCH SUPPORT 1. Co-investigator/Consultant-(Gokina-PI) Mechanisms of uterine vascular adaptation in pregnancy. NHLB. PHS-R01- HL067250-01A2. Awarded 4/1/03-3/31/08. Direct $1,025,000/Total $1,529,958. 10% Effort. 2. Co-investigator- (Osol-PI) Resistance Artery Adaptation in Hypertensive Pregnancy. 1R01HL073895-01A2. Funding Period 4/1/05-3/30/10. $250,000/$1,250,000. 5% Effort. 0.4% Score 120. 3. Alternate Principal Investigator-Cooperative Multicenter Maternal Fetal Medicine Units Network. NICHD. _PHS#5-U10- HD40500-05. 9/6/05-3/31/07. PENDING RESEARCH SUPPORT 1. Principal Investigator-Biomechanical-Biochemical-Molecular Events in Gestational Cervical Remodeling. NIH. Funding period 4/1/06-3/30/11. $225,000/$1,125,000. 30% Effort. New Submission 10/1/05. TEACHING Resident Preceptor: 1. Patricia Farber, M.D. – Residency 1994-1998 Obstetrics and Gynecology, University of Chicago. Currently in private practice. MacNeal Hospital, Berwyn, IL. 2. Nihal Sukkar, M.D. – Residency 1995-1999 Obstetrics and Gynecology, University of Chicago. Currently pursuing fellowship in Maternal Fetal Medicine, Hutzel Hospital, Wayne State University. 3. Stacy Knox, M.D. – Residency 1996-1997 Obstetrics and Gynecology, University of Chicago. Transferred to University of Maryland Department of Obstetrics and Gynecology. 4. Maureen Tart, M.D. – Residency 1999- 2000 Obstetrics and Gynecology, Chief Administrative Resident. University of Chicago. Currently in private practice. 5. Kathy Jones, M.D. – Residency 2000-current Obstetrics and Gynecology 6. Mary Janowiak, M.D. – Residency 2003-current Obstetrics and Gynecology Research Advisor: 1. David Colombo, M.D. – 1995-1997. Residency Research Project. Determination of discordance in twin gestations by evaluating estimated fetal weight with different formulae: a retrospective analysis. Fellowship in Maternal Fetal Medicine, Ohio State University. Currently on faculty Ohio State University. 2. Joseph Martin, M.D. – 1995-1997. Residency Research Project. Postmaturity in Twin Gestations. Currently in private practice. MacNeal Hospital, Berwyn, IL. 3. Alwyn Mziray- 1995-1997. Medical Student research project. Determination of discordance in twin gestations by evaluating estimated fetal weight with different formulae: a retrospective analysis. Obtained MBA. Working in Finance. 4. Susan Song- 1996-1997. University of Chicago Undergraduate Research Project (CROP). Postmaturity in Twin Gestations. Currently attending medical school. 5. John Schilling, M.D.- Summer 1996. Medical Student Summer Research Project. Identification of a Novel Gestationally Regulated Gene. Received Honorable Mention. 1998-1999. 4th year Research Project. Recipient of Calvin-Fentress Research Fellowship Award for work on the project- Characterization and Expression of a Novel Gestationally Regulated Gene. Currently in General Surgery Residency John Hopkins University, Baltimore, Maryland. 6. Sadia Haidar – Summer 1997. Medical Student Research Elective. Obstetrics and Gynecology Residency. 7. Maryam Minhaj, M.D. – 1999-current. Residency Research Project. Characterization and expression of rPTGER2 receptor during rat gestation. Private Practice. 8. Sarah Marietti – Summer 2000. Medical Student Summer Research Program. Medical student, University of Arizona School of Medicine. 9. Zandra Wells – Spring and Summer 2000. Medical Student Research Elective. Medical student, University of Chicago Pritzker School of Medicine. 10. Daniel Rychlik – Fellow in Reproductive Endocrinology. 2000-2002 University of Chicago Department of Obstetrics and Gynecology. Private Practice 11. Michal Elovitz – Fellow in Maternal Fetal Medicine. 1999-2001University of Chicago Department of Obstetrics and Gynecology. Faculty University of Pennsylvania. 12. Candace McGregor- Spring and Summer 2001. Medical Student Research Elective. 1st year medical student, University of Chicago, Pritzker School of Medicine. 13. Virginia Sue-Fall and Winter 2001. 4th Year Medical Student Research Elective. Medical student, University of Chicago Pritzker School of Medicine. 14. Kelley Clark- 2003. Fellow Maternal Fetal Medicine. University of Vermont. 15. Helen Feltovich-2003. Fellow Maternal Fetal Medicine. University of Vermont. 16. Marjorie Dixon-2003. Fellow Reproductive Endocrinology and Infertility. University of Vermont University Teaching Roles 1. Medical Student Preceptor: Pritzker School of Medicine, University of Chicago. 2-3 students per rotation. Three 7-8 week rotations per year. 1992-2002. 2. Medical Student Obstetrics and Gynecology Lecture Series: Diabetes in Pregnancy. Pritzker School of Medicine, University of Chicago. Every rotation. 2000-2002. 3. Resident Lecture Series: Department of Anesthesia, University of Chicago, August 28, 1995. Title: Fetal Heart Rate Monitoring in Obstetric Emergencies. 4. Resident Lecture Series: Department of Anesthesia, University of Chicago, November 4, 1996. Title: Obstetric Emergencies. 5. Resident Lecture Series: Department of Obstetrics and Gynecology, University of Chicago, May 1997. Title: Multiple Gestations. 6. Resident Lecture Series: Department of Obstetrics and Gynecology, University of Chicago, January 1998. Title: Invasive Obstetrical Procedures. 7. Resident Lecture Series: Department of Obstetrics and Gynecology, University of Chicago, June 1998. Title: Physiologic Changes of Pregnancy. 8. Resident Lecture Series: Department of Anesthesia, University of Chicago, September 11, 1998. Title: Uterine Rupture- Obstetric Emergencies. 9. Resident Lecture Series: Department of Anesthesia, University of Chicago, August 26, 1999. Title: Surgical Obstetric Emergencies. 10. Resident Lecture Series: Department of Anesthesia, University of Chicago, August 23, 2001. Title: Fetal Monitoring and Obstetric Emergencies. 11. Resident Lecture Series: Department of Obstetrics and Gynecology, University of Vermont September 2002. Title: Alloimmunization. 12. Resident Lecture Series: Department of Obstetrics and Gynecology, University of Vermont, March 2003. Title: Peurperium 13. Medical Student Preceptor: University of Vermont College of Medicine. 1 student per rotation. Four 6-7 week rotations per year. 2002-2004. 14. Medical Student Obstetrics and Gynecology Lecture Series: Diabetes in Pregnancy. University of Vermont College of Medicine. Every rotation 2002-2004. 15. Perinatal Research Seminar: Mechanisms of Cervical Remodeling. Brown University. Kilguss Research Institute. May 2005. 16. Medical Student Preceptor: Brown University. 2 students. Two 7 week rotations. 2005. Hospital Teaching Roles 1. Resident Lecture Series: Department of Obstetrics and Gynecology. Brown University, WIHRI, September 2004. Title: Cervical Ripening. 2. MFM Fellows Lecture Series: Department of Obstetrics and Gynecology, WIHRI, Brown Medical School, November 2004. Title: Mechanisms of Cervical Ripening. 3. Resident Lecture Series: Department of Obstetrics and Gynecology. Brown University, WIHRI, January 2005. Title: Assessment of Fetal Growth. 4. Resident Lecture Series: Department of Obstetrics and Gynecology. Brown University, WIHRI, January 2005. Title: Obstetric Creog Review: Jeopardy. 5. Perinatal Management Conference: Division of Neonatology. Brown University, WIHRI, April 20, 2005. CPC: Chorioangioma. 6. Perinatal Management Conference: Division of Neonatology. Brown University, WIHRI, August 17, 2005. CPC: Severe IUGR. 7. MADAM Conference: Division of Pediatric Surgery. Brown University, WIHRI, August 5th, 2005. Title: Fetal Renal Masses. 8. Resident Lecture Series: Department of Obstetrics and Gynecology. Brown University, WIHRI, September 23, 2005. Title: Postdates Pregnancy.