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Alzheimer's Disease is multifactorial and many biochemical pathways are deranged. A major challenge is to determine their temporal sequence, relative importance, and which are causative, secondary or self repairing. The end result, neuron and synapse loss and accumulation of damaged proteins (amyloids), will require concurrent therapies to arrest or reverse. We explore various targets of amyloid damage, e.g. energy production, protein clearance mechanisms, signaling pathways, calcium regulation and the replication machinery. Several of these are specific enough to have drug discovery potential.
Overview | Research | Publications
Dr Querfurth received his M.D. and Ph.D.in neuroscience at U. of Rochester, NY. Thereafter, he completed residencies in Internal Medicine and Neurology at U. of Washington, Seattle. Next, he completed a clinical and basic research fellowship in memory disorders at the Brigham and Women's Hospital, HMS, Boston. Since then, Dr. Querfuth has pursued independent research in Alzheimer's disease and a related condition, Inclusion Body Myositis, first within the Tufts University School of Medicine and now at Brown University. He is also developing a technology to non-invasively measure intracranial pressure. He co-directs the Memory clinic at Rhode Island Hospital and divides his time into clinical practice and basic research. |
 HENRY QUERFURTH, MD PhD http://research.brown.edu/myresearch/Henry_Querfurth Are you Henry Querfurth? Click here to edit your research profile. |
