Gideon Koren's research focuses on the regulation of expression voltage-gated potassium channels and mechanisms of sudden death. One of his current research projects involves rabbits expressing dominant negative transgenes that suppress the expression of repolarization currents in the heart. Transmitters are implanted to monitor the heart rhythm to help determine when and why they might die of ventricular arrhythmias. In addition, Koren's group is studying the transcriptional regulation and trafficking of these channels.
My research program is aimed at the understanding of the pathogenesis of cardiac arrhythmias. Our approach involves three main lines of investigation: 1) Elucidation of transcriptional program(s) that regulate the expression of membrane polypeptides involved in determining the duration of cardiac action potential; 2) Investigation of the trafficking and localization of voltage-gated potassium channels in the heart; and 3) Creation of genetically modified animal models for studying sudden cardiac death.
GIDEON KOREN, MD
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