Ulrike Mende is interested in the functional role of G proteins (GTP-binding proteins) and their regulators (Regulators of G protein Signaling) in the heart. They are crucial for the transmission of signals from the cell surface to the inside. Changes in their amount or function often lead to compromised cardiac function and disease, such as hypertrophy and failure. Our goal is to delineate the underlying molecular mechanisms and devise new therapeutic strategies.
Dr. Mende attended Medical School at the University of Hamburg in Germany, followed by 7 years postdoctoral training in the Department of Pharmacology at the University of Hamburg and in the Cardiovascular Division of Brigham and Women's Hospital and Harvard Medical School. She launched a career as an independent scientist and principal investigator at Brigham and Women's Hospital and was promoted at Harvard Medical School to Instructor in 1995 and to Assistant Professor of Medicine in 2000. In 2005, Dr. Mende was recruited by Rhode Island Hospital and Brown Medical School as an Associate Professor of Medicine to help establish a new Cardiovascular Research Center. Her research focuses on cell signaling in heart cells under normal and pathophysiological conditions. Her work has been funded by the American Heart Association (AHA) and the National Institutes of Health (NIH), where she has also been serving as grant reviewer for many years.
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