We study the roles of brain insulin deficiency and insulin resistance in neurodegeneration. Three diseases of major interest to us are: Alzheimer's, alcoholic neurodegeneration, and fetal alcohol syndrome. Experimentally, we examine how insulin deficiency and/or insulin resistance leads to neuronal death, reduced energy metabolism, and decreased neurotransmission. We also investigate therapeutic measures to prevent or reverse brain abnormalities caused by insulin resistance (Type 3 diabetes).
I am a physician scientist who directs basic and translational research in the laboratory. I also perform clinical service work in Neuropathology. This activity includes teaching residents and students. My research efforts are mainly focused on understanding the role of insulin and insulin-like growth factor resistance in relation to neurodegeneration caused by Alzheimer's disease and chronic alcohol abuse.
SUZANNE DELAMONTE, MD, MPH
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