Cancer genomics and systems biology
We are exploring the role of RNA processing in response to hormones such as estrogen in breast cancer. We are identifying novel components mediating hormone control of cancer cells that are regulated post-transcriptionally.
We are also probing hormone combinations mediating cancer cell growth and death. We are testing how these regulatory networks affect cancer cells in mouse models and in genomic data obtained from patients.
Dr. Brodsky received his BA from the University of Pennsylvania where he worked with Dr. Ponzy Lu exploring DNA dynamics during electrophoresis. Dr. Brodsky recieved his PhD from MIT working with Dr. James R. Williamson where he developed a structural model of the HIV tat-TAR protein-RNA interaction using NMR spectroscopy.
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