The Directory of Research and Researchers at Brown: Alexander Brodsky

Cancer genomics and systems biology

We are exploring the role of RNA processing in response to hormones such as estrogen in breast cancer. We are identifying novel components mediating hormone control of cancer cells that are regulated post-transcriptionally.

We are also probing hormone combinations mediating cancer cell growth and death. We are testing how these regulatory networks affect cancer cells in mouse models and in genomic data obtained from patients.

Overview | Research | Grants/Awards | Teaching | Publications

Dr. Brodsky received his BA from the University of Pennsylvania where he worked with Dr. Ponzy Lu exploring DNA dynamics during electrophoresis. Dr. Brodsky recieved his PhD from MIT working with Dr. James R. Williamson where he developed a structural model of the HIV tat-TAR protein-RNA interaction using NMR spectroscopy.

Dr. Brodsky received postdoctoral training from Dr. Pamela A. Silver at the Dana-Farber Cancer Institute/Harvard Medical School where he discovered mechanisms of mRNA export. He was among the first to use chromatin immunoprecipitation combined with genomic tiling arrays to define the coupling of transcription and mRNA processing.

Dr. Brodsky joined the MCB department and the Center of Genetics and Proteomics at Brown University in 2005.

Download Alexander Brodsky's Curriculum Vitae in PDF Format

ALEXANDER BRODSKY
Assistant Professor of Medical Science
Molecular Biology, Cell Biology, & Biochemistry

E-mail: Alexander_Brodsky@brown.edu

Alexander Brodsky's Brown Research URL:
http://research.brown.edu/myresearch/Alexander_Brodsky

Collaborators at other institutions:
Colin Collins Prostate Cancer Centre, Vancouver, Canada
Peter Smith MBL, Woods Hole, MA

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Research at Brown: The Directory of Research and Researchers: Research Profile