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We are interested in establishing the impact of hepatitis B virus genotypes and naturally occurring mutations on viral genome replication, protein expression (core protein and e antigen), and virus particle release. It is well documented that certain mutations and some viral genotypes are closely associated with the development of liver cancer, but the molecular mechanisms remain unknown. We use molecular approaches to address this important medical problem.
Overview | Research | Grants/Awards | Teaching | Publications
MD: Shanghai Medical University, Shanghai, China (1983). Ph.D.: Claud-Bernard University, Lyon, France (1992). Postdoctoral training: Harvard Medical School (1993-1999). Current employment: Associate Professor of Medicine, Liver Research Center, Rhode Island Hospital, Brown University. Research interest: hepatitis B virus: Viral genotypes and naturally occurring mutants. We use molecular approaches to establish the biological consequences of viral genetic variability, especially mutations implicated in pathogenesis.
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