I study life history evolution with an emphasis on senescence. Senescence intrigues because it seems counter-intuitive to the process of natural selection. How can physiological and demographic functions deteriorate with age in the face of selection that relentlessly increases mean fitness? And, how has evolution led to the tremendous variation in life span we observe among individuals, species and taxa? The solutions to these questions lie in understanding the way selection acts on age-structured populations, and in discovering how gene expression affects fitness. My research uses multiple approaches to develop a basic understanding of the genetics, mechanisms and evolution of senescence.
Marc Tatar is Professor in The Division of Biology and Medicine at Brown University. Dr. Tatar has studied the demography, evolution and genetics of aging working with a variety of insect systems to explore the regulation and basic mechanisms of life history traits and senescence. Current work in the Tatar laboratory focuses on genetic analysis of Drosophila to understand how insulin/IGF signals and lipid hormones regulate aging, and how these endocrine signals interact with nutrition. Dr. Tatar received his Ph.D. from UC Davis in the laboratory of James Carey and completed post-doctoral training at the University of Minnesota with James Curtsinger. Dr. Tatar is an Ellison Senior Scholar, founding Joint Editor-in-Chief of Aging Cell, and a past member of the Board of Review Editors for Science.
MARC TATAR, PHD, MA
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Researchers discover the first compounds that slow aging across species
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