Our laboratory has worked on the regulatory genes of HIV-1. We were particularly interested in understanding the mechanism of action of the tat regulatory gene. Tat is unique among transcriptional activators in that the gene product interacts with a secondary structural element at the 5' at the end of the RNA transcript. We are also interested in the role of HIV in malignancy, particularly B-cell lymphomas. We have shown that HIV can infect human B-cells in a CD4 independent manner.
Peter Shank received his BS from Cornell University and his Ph.D. from The University of North Carolina at Chapel Hill. He was a postdoctoral fellow at UCSF working with Michael Bishop and Harold Varmus on retroviruses. He joined the Brown faculty in 1978 and has worked with both avian and human retroviruses. He has published on extensively on the molecular biology of retroviruses and has served on editorial boards and numerous NIH review panels.
PETER SHANK, Ph.D.
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