Our laboratory focuses on the regulation of normal and abnormal cellular growth. We use liver as the model tissue for our studies. We rely on animal models, cell culture, and human tissue. We study control of fetal growth, tissue regeneration, and tissue injury, including injury that can lead to cancer. Our goals are to understand how nutrition and other environmental factors affect cell growth, and to develop cell-based therapeutic approaches suitable for liver diseases, including cancer.
Following medical school, I pursued clinical training in pediatrics. It was during my residency that I became interested in biomedical research. This led to a metabolism fellowship, clinical training in metabolism and pediatric endocrinology, and a research focus on mechanisms that regulate somatic growth. My laboratory has had continuous NIH funding since 1983, and I have been a trainer in Brown's MCB and Pathobiology training programs since 1995.
PHILIP GRUPPUSO, MD, University of Rochester, 1977
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