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In our laboratory, we use many basic techniques in biochemistry and molecular and cell biology to investigate interdisciplinary problems in reproductive toxicology/biology. A major issue in environmental health is mixed exposures. We are using prototypal cell-type specific testicular toxicants to dissect interactions and inter-dependencies among those cells responsible for successful spermatogenesis. Ongoing experiments evaluate the potential roles of local paracrine growth and death factors in the regulation of spermatogenesis following injury. Knockout and transgenic mice are used to investigate these growth and death factor pathways.
Overview | Research | Grants/Awards | Teaching | Publications
Kim Boekelheide is Professor of Pathology and Laboratory Medicine at the Brown University School of Medicine. He received his B.A. from Harvard University, and M.D. and Ph.D. from Duke University. His research examines fundamental molecular mechanisms by which environmental and occupational toxicants induce testicular injury. Current projects include the study of co-exposure synergy using model testicular toxicants and the effects of in utero endocrine disruptor exposure on steroidogenesis and a predisposition to cancer. He is Director of the Brown University Superfund Basic Research Program. His research has been continuously funded by the National Institute of Environmental Health Sciences since 1985 and he has received several awards including a Burroughs Wellcome Toxicology Scholar Award (1994-1999).
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 KIM BOEKELHEIDE, MD, PHD http://research.brown.edu/myresearch/Kim_Boekelheide On The Web: Brown Wins Major Award to Improve Environment, Protect R.I. Health Brown collaborators:
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