Research in our laboratory has been focused on signal transduction in response to cellular environmental changes for cell differentiation and development under physiological and diseased conditions (e.g., inflammatory and transformed). We recently discovered that cytokines and growth factors trigger acetylation/methylation cascade in mammalian cells for signal transduction. Utilizing antibody array and nanometer technologies, we are uncovering novel protein posttranslational modifications for distinct signal transduction and transcription events involved in normal, inflammatory, and cancer cellular development.
Chin was appointed an assistant professor of Pathology Department Brown University in October, 1998 after completing the postdoctoral training at Pathology Department, Yale Medical School. Chin relocated his lab in Surgery Department of Rhode Island Hospital in April, 2002. Chin was promoted as associate professor in 2004. Chin's laboratory was the first to develop antibody array technology for protein profile analysis in mammalian cells. His lab uncovered the role of reversible lysine acetylation process in regulating oncogene STAT3 activity in signal transduction and transcription in prostate and breast cancer cells. Recent publications from his lab revealed an important role of acetylation and deacetylation in cytokine receptor signal transduction.
Y. EUGENE CHIN, Ph.D., NYU, 1994
On The Web:
Surprising Study Reveals How Cancer-Causing Protein Activates
Brown researchers discover cancer 'on-off switch'
Brown Researchers Make Major Signal Transduction Discovery
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