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My lab uses a combination of computational biology and high throughput genomics techniques to identify functional elements in the genome. I am particularly interested in sequence elements that regulate RNA splicing. Specific projects that move beyond identifying splicing signals include 1) understanding how particular arrangements of sequence elements are read by the splicing machinery, 2) identifying mutations/polymorphisms that disrupt splicing in the human population, and 3) investigating the evolution of gene expression signals.
Overview | Research | Grants/Awards | Teaching | Publications
I majored in chemistry at Oberlin College then worked briefly as a freelance journalist and in several other jobs in New York City before starting graduate school at Columbia University working in the Chasin lab where I learned library/selection approaches in somatic cell genetic systems. I then moved to Boston for a postdoc at MIT in Phil Sharp's Lab. My interest in computational methods brought me in close contact with Chris Burge's Lab and as a collaborative project we developed the first computational screen for enhancer sequences.
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