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At critical points in chronic liver injury the potential for liver repair is lost. Timely surgical and medical treatment, however, initiates liver repair in infants, children, and adults, interrupting the cycle of inflammation and hepatic fibrosis. The subsequent cellular regulation of matrix protein degradation and resolution of injury-dependent fibrosis is unknown. The long-term goals of our studies are to define the molecular mechanisms required for ordered matrix resorption and liver repair.
Overview | Research | Grants/Awards | Teaching | Publications
Thomas F. Tracy, Jr is Vice Chairman of the Department of Surgery and Professor of Surgery and Pediatrics. He is the Residency Director in Pediatric Surgery as well as Pediatric Surgeon-in-Chief, Hasbro Children's Hospital. After training in surgery at MCV and pediatric surgery at Columbia, Dr. Tracy came to Brown as an NIH funded investigator who has authored well over 100 peer-reviewed manuscripts. He is a study section ember for NIDDK and a director of the American Board of Surgery and the Pediatric Surgery Board of the ABS. He is on the Executive Board of the American Pediatric Surgical Association and The Pediatric Surgery Council of the American College of Surgeons. Dr. Tracy is an elected member of the leading national surgical societies. His research interests examine hepatic repair mechanisms following liver injury that currently focus on the cellular mechanisms for matrix metalloproteinase activity required for successful liver repair.
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