Steven Moss studies the role of the bacterium, Helicobacter pylori, in gastric (stomach) cancer.
H. pylori is found commonly in the human stomach and is highly adapted for infection lasting decades. Its presence is associated with peptic ulcer disease, chronic gastritis and gastric adenocarcinoma, but how this bacterium causes disease is not well understood. We examine interactions between H. pylori and the human gastric epithelium which may be relevant to the pathogenesis of these diseases. Our current focus is on the effects of H. pylori in modulating gastric epithelial cell cycle control, via decreasing the expression of gastric p27(kip1), an important cell cycle regulatory and tumor suppressor protein.
Steven Moss is a UK-trained physician-scientist whose research focuses on the role of H. pylori infection in gastric cancer. He is a clinical gastroenterologist at Rhode Island Hospital and Director of the Brown Gastroenterology Fellowship Training Program.
STEVEN MOSS, MD
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Steven Moss, MD
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