The focus of my research is to understand the molecular basis of MAP kinase regulation by its interaction with kinases, via scaffolding proteins, and phosphatases. We combine structural data from X-ray crystallography and NMR spectroscopy with biophysical data from ITC, CD spectroscopy and kinetics to understand how MAPK activity is controlled in vitro and in vivo. We are also investigating the structures and functions of bacterial proteins that play central roles in antibiotic resistance.
Professor Page received dual B.S. degrees with honors in Biochemistry and Applied Mathematics from the University of Arizona in 1993 and completed her graduate work in Chemistry with Dr. C. E. Schutt as an NSF graduate and Harold W. Dodds fellow at Princeton University (PhD, 2000). From 2000 - 2003, she was a NIH NRSA post-doctoral fellow at The Scripps Research Institute with Dr. Ray Stevens, after which she joined the Joint Center for Structural Genomics with Dr. Ian Wilson to become the core leader of high-throughput crystallization group. In 2005, she joined the Molecular Biology, Cell Biology and Biochemistry department at Brown University as an assistant professor. The focus of her research is to elucidate the structures and dynamics of the transient macromolecular complexes that drive signaling in eukaryotic and prokaryotic cells.
REBECCA PAGE, PhD
On The Web:
Page Laboratory Home Page
Rebecca Page - publications list
Chairman Obey visits structural biology laboratories
Dr. Page selected as a 2007 ACS Research Scholar
Collaborators at other institutions:
Thomas K. Wood
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