The Directory of Research and Researchers at Brown: Mayank R Mehta

Our research focuses on understanding the neural mechanisms of learning and memory. A brain region called the hippocampus is known to be critical for learning. Our research has shown that there are large changes in the activity of hippocampal of neurons with experience. For example, the firing rate of these neurons doubles within just a few trials. Further, with learning, these neurons' activity starts to predict or anticipate the upcoming stimulus. Our research has also shown that brain rhythms play a key role in this anticipatory learning. Future research will reveal the synaptic and cellular mechanisms responsible for these results and their influence on behavior.

Overview | Research | Grants/Awards | Teaching | Publications

Recent Publications:

01. K. L. Hoffman, F. P. Battaglia, K. Harris, J.N MacLean, L. Marshall and M. R. Mehta. 'The upshot of up-states in the neocortex: from slow oscillations to memory formation'. J. Neurosci. 27: 11838 - 11841 (2007).

02. T. T. G. Hahn, B. Sakmann and M. R. Mehta, 'Differential responses of hippoocampal subfields to cortical up-down states'. PNAS 104: 5169-5174 (2007).

03. M. R. Mehta 'Fascinating Rhythm'. Nature 446:27-28 (2007).

04. M. R. Mehta 'Cortico-hippocampal interaction during up-down states and memory consolidation'. Nature Neurosci. 10: 13-15 (2007).

05. T. T. G. Hahn, B. Sakmann and M. R. Mehta , 'Phase locking of hippocampal iterneurons' membrane potential to neocortical up-down states'. Nature Neurosci. 9, 1359:1361 (2006).

06. M. R. Mehta, 'Role of rhythms in facilitating short-term memory', Neuron, 45, 7:9 (2005).

07. M.R. Mehta 'Cooperative LTP can map memory sequences on dendritic branches'. Trends in Neuroscience, 27 69:72 (2004).

08. M.R. Mehta, A. K. Lee & M. A. Wilson 'Learning behavioral sequences: Open questions and potential solutions', Trends in Neuroscience, 27 14:15 (2004).

09. C. C. H. Petersen, T. T. G. Hahn, M. R. Mehta, A. Grinwald & B. Sakmann, 'Interaction of sensory responses with spontaneous depolarisation in layer 2/3 barrel cortex'. PNAS USA, 100: 13638-13643 (2003).

10. M. R. Mehta, A. K. Lee & M. A. Wilson, 'Role of Oscillations and Experience in Transforming a Rate Code into a Temporal Code'. Nature, 417:741-746 (2002).

11. M. R. Mehta, `Neuronal Dynamics of Predictive Coding', The Neuroscientist, 7:490-495 (2001).

12. M. R. Mehta & M. A. Wilson, 'From Hippocampus to V1: Effect of LTP on Spatio-Temporal Dynamics of Receptive Fields', Neurocomputing 32:905-911 (2000).

13. M. R. Mehta, M. C. Quirk & M. A. Wilson, 'Experience-Dependent Asymmetric Shape of Hippocampal Receptive Fields', Neuron 25:707-715 (2000).

http://neurophysics.brown.edu

Download Mayank R Mehta's Curriculum Vitae in PDF Format

MAYANK R MEHTA, M. Sc., Ph. D.
Assistant Professor
Neuroscience
Phone: +1 401 863 9727
Phone 2: +1 401 863 9727
E-mail: Mayank@brown.edu

Mayank R Mehta's Brown Research URL:
http://research.brown.edu/myresearch/Mayank_R_Mehta

On The Web:
Mehta Lab
http://neurophysics.brown.edu

Brown collaborators:

Collaborators at other institutions:
Prof. Bert Sakmann, Max Plank Institute, Heidelberg.

Prof. Peter Seeburg, Max Plank Institute, Heidleberg.

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