Overview  |  Research  |  Grants/Awards  |  Teaching  |  Publications

Professor John Sedivy joined the Brown Faculty in 1996 and is a member and Chair of the Department of Molecular Biology, Cell Biology and Biochemistry. He obtained his PhD from Harvard in 1985, and subsequently trained with the Nobel Laureate Philip Sharp at the MIT Center for Cancer Research. He started his independent research career at Yale University in 1988.

John Sedivy is recognized for his efforts in mammalian genetics, having developed and pioneered methods for gene targeting of somatic cells. His research on cell cycle regulation and signal transduction, focusing on the Myc oncogene, has been continuously funded by the NIH since 1989. In 1995 his laboratory isolated the first viable gene knockouts of the c-myc oncogene, and these cell lines have become the premier model system in the Myc field. In 1997 his laboratory succeeded in isolating the first homozygous gene knockout in a normal human cell. Since 1998 his laboratory has pursued, in addition to the Myc project, studies of human replicative senescence (in vitro cell aging).

In addition to writing the first comprehensive book on gene targeting in 1992, John Sedivy has published over 90 original articles. He has served on numerous study sections and advisory committees at the NIH, the American Cancer Society, and the US Army Breast Cancer Initiative. He has consulted extensively on the genetic manipulation of mammalian cells to the biotech industry, including Biogen, Eli Lilly & Co., Abbott Laboratories, and Millenium Pharmaceuticals.

In 2000 John Sedivy became the Principal Investigator of a Center of Biomedical Research Excellence (COBRE) award from the National Center for Research Resources (NIH), an award that to date has brought over $ 22 million to Brown University over a period of 10 years. The COBRE award has been used to establish a Mouse Knockout and Transgenic Core Facility, a Genomics and Bioinformatics Core Facility, and to fund numerous pilot projects in the Division of Biology and Medicine. Most recently, John Sedivy has spearheaded the establishment of a Center for Genomics and Proteomics at Brown University, and the development of new biomedical research space in the Jewelry District of Providence.

Download John Sedivy's Curriculum Vitae in PDF Format