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Ubiquitin-dependant proteolysis is a major mechanism used in cells to control protein levels. E3s, or ubiquitin ligases, are proteins that are responsible for recognition of the substrates targeted for degradation. One important class of E3s are the cullins that function as parts of multi-subunit complexes which are assembled in a modular fashion. Cullins have been shown to be involved in a large variety of biological processes, including cell cycle control, removal of N-glycosylation containing proteins, transcriptional control, hormonal regulation, differentiation, development, and prevention of neurological disorders. Our laboratory is interested in understanding how cullins function in mammalian cells.
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University of Oregon
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 JEFFREY SINGER, PhD http://research.brown.edu/myresearch/Jeffrey_Singer On The Web: Jeffrey Singer Brown collaborators:Are you Jeffrey Singer? Click here to edit your research profile. |
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