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                    [id] => 1265715242
                    [firstname] => Erica
                    [lastname] => Larschan
                    [degrees] => Ph.D
                    [title] => Assistant Professor of Biology
                    [department] => Molecular Biology, Cell Biology, & Biochemistry
                    [phone] => +1 401 863 1070
                    [phone2] => 
                    [email] => Erica_Larschan@brown.edu
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                                    [0] => Pew Scholars Directory
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                                    [0] => Today at Brown
                                    [1] => http://today.brown.edu/faculty/2009/larschan
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                                    [0] => Larschan lab featured at LiveScience and ms-NBC
                                    [1] => http://www.livescience.com/13042-male-sex-chromosome-gene-expression-110302.html
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                    [summary] => Our long-term goal is to define how genes are identified for coordinate regulation, the key initial step in their regulation. We are using genomic, genetic and biochemical approaches to define how domains of active transcription are formed in real-time.
                    [bio] => Coordinate gene regulation is a fundamental process essential to all cells from the germ line to the immune system. Our long-term goal is to define how genes are identified for coordinate regulation, the key initial step in their regulation.  Dosage compensation is one of the best model systems for studying this process because all of the genes on a single chromosome are specifically identified and co-regulated.  Drosophila, like mammals, increase the transcript levels of a large number of diversely-regulated genes along the length of the single male X-chromosome precisely two-fold relative to each female X-chromosome.  <br />
<br />
We are developing innovative approaches to understanding how dosage compensation in Drosophila is established, the critical first step in coordinate regulation.  By combining genetic, biochemical, and genomic approaches,  we will address the following key overall question: How are global and gene-specific transcriptional regulatory signals integrated to precisely regulate genes?
                    [interests] => Coordinate gene regulation is a fundamental process essential to all cells from the germ line to the immune system. Our long-term goal is to define how genes are identified for coordinate regulation, the key initial step in their regulation.  Dosage compensation is one of the best model systems for studying this process because all of the genes on a single chromosome are specifically identified and co-regulated.  Drosophila, like mammals, increase the transcript levels of a large number of diversely-regulated genes along the length of the single male X-chromosome precisely two-fold relative to each female X-chromosome.  <br />
<br />
We are developing innovative approaches to understanding how dosage compensation in Drosophila is established, the critical first step in coordinate regulation.  In this way, we will address the following key overall question: How are global and gene-specific transcriptional regulatory signals integrated to precisely regulate genes?  By combining genetic, biochemical, and genomic approaches, we are addressing the following fundamental questions: 1) How are the functions of non-coding RNAs and cis-acting sequences integrated?; 2) How do multiple chromatin marks act together during targeting of transcription complexes?; 3) How can local enrichment of a DNA sequence generate a sub-nuclear domain?
                    [fresearch] => 1) Pew Biomedical Scholars program &#9;<br />
7/1/2011-6/30/2015&#9;&#9;&#9;&#9;&#9;$220,812 direct costs&#9;&#9;7% effort<br />
"Establishing domains of coordinate gene regulation"<br />
Role: PI<br />
<br />
Project Goals: The proposed research will examine how coordinate gene regulation is established in Drosophila.  The Pew grant will provide funding for one graduate student and related supplies to work on high-risk aspects of understanding how dosage compensation is established in the early embryo.  <br />
<br />
2) NIH R01 GM098461-1&#9;&#9;<br />
7/1/2011-6/30/2016&#9;&#9;&#9;&#9;&#9;$1,250,000&#9;&#9;&#9;33% effort<br />
 "Establishing coordinate gene regulation during Drosophila dosage compensation"<br />
Role: PI<br />
<br />
Project Goals: This project will reveal how the Drosophila male X chromosome is established as a domain of coordinate gene regulation.  The experiments proposed in the NIH R01 proposal do not overlap with those proposed here.<br />
<br />
<br />
 3) Brown ADVANCE Grant from NSF HRD-0548311&#9;&#9;Effort: 0 months/0%<br />
"Using Next Generation sequencing to study dosage compensation in Drosophila"<br />
4/01/2010-6/30/2011&#9;&#9;&#9;&#9;&#9;&#9;&#9;$15,000<br />
Role: PI<br />
<br />
Project Goals: Use next-generation sequencing to understand Drosophila dosage compensation.  This is a seed award that was used to generate some of the preliminary data for this proposal. It will be ending prior to the start date of the ACS award.<br />
<br />
4) RI-INBRE NIH Seed Award   P20RR016457-10&#9;&#9;&#9;Effort: 0.15 months/3%<br />
"Establishing sub-nuclear domains of coordinate gene regulation"<br />
12/1/2010-4/30/2011&#9;&#9;&#9;&#9;&#9;&#9;&#9;$30,000<br />
Role: PI<br />
<br />
Project Goals:  Understand how coordinate gene regulation is established.  This is a seed award that was used to generate some of the preliminary data shown in this proposal.  It will be ending prior to the start of the ACS award.<br />
<br />
5) Brown Salomon Award&#9;&#9;&#9;&#9;Effort: 0 months/0%<br />
"Establishing sub-nuclear domains of coordinate gene regulation"<br />
2/28/2011-2/27/2012&#9;&#9;&#9;&#9;&#9;$15,000<br />
Role: PI<br />
<br />
Project Goals:  This grant provides internal seed funding to examine how coordinate gene regulation is established in Drosophila using a novel induction system.  These experiments provide preliminary data relevant to this project but do not overlap with the experiments proposed here.<br />
<br />
6) Rhode Island Foundation Research Grant&#9;Effort: 0.3 Months/2.5%<br />
"Establishing domains of coordinate gene regulation"<br />
6/01/2011-5/31/2012&#9;&#9;&#9;&#9;&#9;$15,000<br />
Role: PI<br />
<br />
Project Goals: This grant provides local seed funding to examine how coordinate gene regulation is established in Drosophila using a novel induction system.    These experiments provide preliminary data relevant to this project but do not overlap with the experiments proposed here.<br />
<br />
<br />
2) Pending:<br />
<br />
American Cancer Society Research Scholar Grant<br />
1/1/2012-12/31/2016&#9;&#9;&#9;&#9;&#9;$600,000&#9;&#9;&#9;18% effort<br />
Role: PI<br />
"Targeting histone acetylation within complex genomes"<br />
Project goals: Determine how histone acetylation is targeted within cancer genomes
                    [awards] => Faculty Awards<br />
<br />
2011       Pew Biomedical Scholar<br />
<br />
2011       Ellison Foundation New Scholar (Declined)<br />
<br />
Academic<br />
<br />
1994&#9;Wellesley College: four-year full tuition scholarship <br />
<br />
1995&#9;NIH Research Experience for Undergraduates fellowship<br />
<br />
1996&#9;Staley Fellowship for cancer research<br />
<br />
1997&#9;American Cancer Society Undergraduate research fellowship<br />
<br />
1998&#9;National Barry M. Goldwater Scholarship in Science<br />
<br />
1998&#9;Mary F.C. Gross Prize for Academic Achievement<br />
<br />
1998&#9;Horton-Hallowell Fellowship for graduate study<br />
<br />
1998&#9;Wellesley College Valedictorian (summa cum laude)<br />
<br />
2002&#9;Albert J. Ryan Scholar at Harvard Medical School<br />
<br />
Fellowships<br />
<br />
2004&#9;NIH F32 Postdoctoral Fellowship (declined)<br />
<br />
2004&#9;American Cancer Society Postdoctoral Fellowship (declined)<br />
<br />
2004&#9;Leukemia and Lymphoma Postdoctoral Fellow<br />
<br />
2008&#9;Medical Foundation Charles A. King Trust Postdoctoral Fellow<br />
<br />
<br />
Honorary Societies<br />
<br />
1997&#9;Phi Beta Kappa, Wellesley College, Wellesley, MA<br />
<br />
1998&#9;Sigma Xi Science Honor Society, Wellesley College, Wellesley, MA
                    [affiliations] => Member, Genetics Society of America
                    [teaching] => Seminar on Transcription and Chromatin<br />
<br />
Molecular and Cell Biology
                    [collab] => Peter J. Park
Lori Pile
Richard Kelley
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                    [profile_url] => research.brown.edu/myresearch/Erica_Larschan
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<img height=32 src="/ttfs/drawstring_header.php?headertext=ERICA LARSCHAN" alt="ERICA LARSCHAN">  
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      Our long-term goal is to define how genes are identified for coordinate regulation, the key initial step in their regulation. We are using genomic, genetic and biochemical approaches to define how domains of active transcription are formed in real-time.      </p>
      <div id="researcher-pages">
	<p><strong>Overview</strong>&nbsp;&nbsp;|&nbsp;&nbsp;<a href="javascript:set_html('','/research/profile_myresearch.php?id=1265715242','researcher-pages');">Research</a>&nbsp;&nbsp;|&nbsp;&nbsp;<a href="javascript:set_html('','/research/profile_grants.php?id=1265715242','researcher-pages');">Grants/Awards</a>&nbsp;&nbsp;|&nbsp;&nbsp;<a href="javascript:set_html('','/research/profile_teaching.php?id=1265715242','researcher-pages');">Teaching</a>&nbsp;&nbsp;|&nbsp;&nbsp;<a href="javascript:set_html('','/research/profile_publications.php?id=1265715242','researcher-pages');">Publications</a></p><p><img src="/images/subhead/biography.gif" alt="Biography" width="225" height="16" style="padding-top:10px;"></p><p>Coordinate gene regulation is a fundamental process essential to all cells from the germ line to the immune system. Our long-term goal is to define how genes are identified for coordinate regulation, the key initial step in their regulation.  Dosage compensation is one of the best model systems for studying this process because all of the genes on a single chromosome are specifically identified and co-regulated.  Drosophila, like mammals, increase the transcript levels of a large number of diversely-regulated genes along the length of the single male X-chromosome precisely two-fold relative to each female X-chromosome.  <br />
<br />
We are developing innovative approaches to understanding how dosage compensation in Drosophila is established, the critical first step in coordinate regulation.  By combining genetic, biochemical, and genomic approaches,  we will address the following key overall question: How are global and gene-specific transcriptional regulatory signals integrated to precisely regulate genes?</p><p><img src="/images/subhead/curriculumvitae.gif" alt="Curricum Vitae" width="225" height="16" style="padding-top:10px;"></p><p><a href="/pdf/1265715242.pdf?nocache=861742294">Download Erica Larschan's Curriculum Vitae in PDF Format</a></p><p><img src="/images/fimages/1270122634.jpg"><br /><i></i></p></div>
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    <img src="/images/headshot/1265715242.jpg?nocache=1159329156"><p>ERICA LARSCHAN, Ph.D<br />Assistant Professor of Biology<br />Molecular Biology, Cell Biology, & Biochemistry<br />Phone: +1 401 863 1070<br />E-mail: <a href="mailto:Erica_Larschan@brown.edu">Erica_Larschan@brown.edu</a></p>Erica Larschan's Brown Research URL:<br />
 	<strong>http://research.brown.edu/myresearch/Erica_Larschan</strong><br /><br />On The Web:<br /><a href="http://directory.pewscholars.org/scholars/2011-010/" target="new">Pew Scholars Directory</a><br><a href="http://today.brown.edu/faculty/2009/larschan" target="new">Today at Brown</a><br><a href="http://www.livescience.com/13042-male-sex-chromosome-gene-expression-110302.html" target="new">Larschan lab featured at LiveScience and ms-NBC</a><br><p>Collaborators at other institutions:<br>Peter J. Park<br />
Lori Pile<br />
Richard Kelley</p><p>Are you Erica Larschan? <a href="/faculty" target="blank">Click here</a> to edit your research profile.</p>	<p><a href="search.php">Back to search page</a></p>
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<div id="sectionheader"><b><a href="http://www.brown.edu/research/">Research at  Brown:</a></b> <a href="search.php">The Directory of Research and Researchers:</a> Research Profile</div>
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