Our long-term goal is to define how genes are identified for coordinate regulation, the key initial step in their regulation. We are using genomic, genetic and biochemical approaches to define how domains of active transcription are formed in real-time.
Coordinate gene regulation is a fundamental process essential to all cells from the germ line to the immune system. Our long-term goal is to define how genes are identified for coordinate regulation, the key initial step in their regulation. Dosage compensation is one of the best model systems for studying this process because all of the genes on a single chromosome are specifically identified and co-regulated. Drosophila, like mammals, increase the transcript levels of a large number of diversely-regulated genes along the length of the single male X-chromosome precisely two-fold relative to each female X-chromosome.
ERICA LARSCHAN, Ph.D
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