The Directory of Research and Researchers at Brown: Edward Hawrot

We pursue biochemical and pharmacological studies aimed at understanding the fundamental structure-function relationship of nicotinic acetylcholine receptors (nAChRs). We also study the molecular basis for the highly specific recognition of muscle-type nAChRs by certain snake venom-derived toxins classified as alpha-neurotoxins. More recently, we have used homologous recombination techniques to construct a knock-in mouse in which the alpha3 gene encoding one subtype of neuronal nAChRs has been minimally mutated to impart pharmacological sensitivity to the classic nicotinic antagonist, alpha-bungarotoxin. These mice should enable a systematic determination of the role of alpha3-containing nAChRs in behavior and nervous system function.

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EDWARD HAWROT, Ph.D., Harvard University, 1976
Professor
Molecular Pharmacology, Physiology & Biotechnology
Phone: +1 401 863 1034
Phone 2: +1 401 863 6086
E-mail: Edward_Hawrot@Brown.EDU

Edward Hawrot's Brown Research URL:
http://research.brown.edu/myresearch/Edward_Hawrot

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Research at Brown: The Directory of Research and Researchers at Brown: Research Profile