Obesity and its related medical complications including type 2 diabetes, cardiovascular disease, dyslipidemia, and cancer account for more than 300,000 deaths per year in the United States. Obesity occurs as a result of a longstanding imbalance between energy intake and energy expenditure, which is influenced by a very complex set of biological pathway systems regulating appetite. A more thorough understanding of the molecular mechanisms underlying the pathogenesis of obesity and regulation of energy metabolism is essential for the development of effective therapies. My laboratory study the biology of different hypothalamic neuropeptide hormones and enzyme nutrient sensors involved in the regulation of energy balance.
Dr. Eduardo A. Nillni joined the Division of Endocrinology in the Department of Medicine as a member of the research faculty in 1989. His education included a master's degree in Biological Sciences from the University of Buenos Aires, Argentina, and a PhD from the Hadassah Medical School, Hebrew University of Jerusalem, Israel, where he studied the Biochemistry of Parasitic Protozoa. Dr. Nillni did his post-doctoral fellowship in membrane biology of parasitic protozoa at Tufts-New England Medical Center in Boston, and he then became a member of the faculty in 1984. He subsequently shifted his research to the field of Endocrinology and has established a highly productive program studying the role of neuropeptide hormones, nutrient sensors in the hypothalamus and the adiposite hormone leptin involved in the regulation of food intake energy homeostasis.
EDUARDO A. NILLNI, PHD, MS
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