We are interested in the cellular mechanisms used to optimize calcium ion channel function. Calcium ion channels regulate many critical neuronal functions including transmitter release, nerve growth, and synaptic plasticity. Our current research focus is on cell-specific alternative splicing in the mammalian nervous system. We study cellular mechanisms that control calcium channel function in normal as well as in disease states, including chronic pain and mental illness.
I graduated with a PhD in Pharmacology from University College London in 1986. My journey into the world of calcium ion channels started when I joined Richard Tsien as a postdoctoral associate at Yale University School of Medicine and subsequently at Stanford University Medical School. In 1992 I joined the Department of Neuroscience here at Brown where I work closely with undergraduate and graduate students, as well as postdoctoral trainees. I direct the Neuroscience Graduate Program.
DIANE LIPSCOMBE, Ph.D., University College London
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