Pain is a protective mechanism but chronic pain can be life-threatening. It leads to long-term changes throughout the nervous system called 'neuroplasticity'. The immune system is also a defense mechanism and interaction between the nervous and the immune systems influences the intensity and duration of pain secondary to nerve damage. The challenge is to better understand this interaction and to propose approaches that would help in reversing neuroplasticity and consequently chronic pain.
Carl Saab is a PhD Neuroscientist studying nervous system diseases. He obtained his PhD in 2001 from the University of Texas Medical Branch in the field of pain research mapping pain pathways in the cerebellum (thesis advisor WD Willis). He then completed his postdoctoral fellowship in the laboratory of Stephen Waxman at Yale studying sodium channelopathies in pain and multiple sclerosis. Currently Carl is Assistant Professor at Brown University & Rhode Island Hospital, Neurosurgery and Neuroscience.
CARL SAAB, MS, PhD
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